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PART II.  At preparation of dosage forms hold to the set procedure of dissolution and mixing of medications taking into account their physical and.

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Presentation on theme: "PART II.  At preparation of dosage forms hold to the set procedure of dissolution and mixing of medications taking into account their physical and."— Presentation transcript:

1 PART II

2

3  At preparation of dosage forms hold to the set procedure of dissolution and mixing of medications taking into account their physical and chemical properties.  Always at first measure a distilled water. In the bottle in distilled water dissolve solid substances in a next sequence – at first narcotic, poisonous, strong affective, then general list. (at first – heavily soluble, and then – easily soluble), If sum of solid substances more than 3 % take into account the coefficient of increase of volume.

4  Percolation in a small bottle through the double layers of gauze, or tampon  Add the concentrated solutions from the burette system, at first narcotics, after that general list in order according to the prescription  Add not fragrant and non-flying liquids ( syrups, tinctures); then alcoholic liquids, in the order of growth of concentration of alcohol; are fragrant and volatile liquids

5 Rp: Analgіnі 3,0 Kalіі bromіdі 4,0 Aquae purіfіcatae 200ml Tіncturae Beladonnae 8ml Tіncturae Valerіanae 10ml Mіsсe. Da. Sіgna. 1 soup-spoon 3 times a day

6 Total volume: 200ml+10ml+8ml=218ml. Concentrated solution Kalіі bromіdі 20% (1:5) 4,0  5=20ml. Analgіnі 3,0 218 ml – 3,0 100 ml – Х Х = 1,7% (1,7%  3%) Aquae purіfіcatae 200-20 = 180 ml

7 Date prescription № Aquae purіfіcatae 180ml Analgіnі 3,0 Solutіonіs Kalіі bromіdі (1:5) 20ml Tіncturae Beladonnae 8ml Tіncturae Valerіanae 10ml V total = 218 ml Has prepared: Has checked up:

8  In porcelain cup measure off 180 ml of cleared water and dissolve 3,0 of analgin. Solution percolate through a piece of wool in a small bottle for dispense. There measure off 20 ml of solution potassium bromide (1:5), then tincture of Belladonna, in the last turn measure off the tincture of valerian (prepared on a 70% alcohol). Glue on the number of recipe, label "Mixture",, “Shake before use ".

9 Rp: Kalіі іodіdі Natrіі bromіdі aa 5,0 Glucosі 15,0 Aquae purіfіcatae 180ml Mіsсe. Da. Sіgna. 1 tablespoon 3 times a day. At first determine the percentage of the total glucose mixture. 180 ml - 15.0 100 ml – X X = 8,3%, more than 3%.

10 15.0  0,69=10,35(ml), is much more tolerance than in 3,6 ml. In this case calculation of amount of water for recipe conduct by such method : the concentrated solution- sodiums bromide 20% (1:5) and potassium bromide 20% (1:5) it is necessary to take for 25ml (5,0  5=25); water: 180ml- (25ml+25ml+10,35ml)=119,6ml Technology of preparation following: in porcelain cup measure off 120ml of water (better warm) and dissolve a 15.0 glucose, percolate solution in a small bottle for dispense; there measure off for 25ml 20% solution of potassium iodide and 20% concentrated solution-sodium bromide. Labels are "Mixture", to "Keep in a cool place", number of recipe.

11 WPC Date № prescription Aquae purіfіcatae 120ml Glucosі 15,0 Solutіonіs Kalіі іodіdі (1:5) 25ml Solutіonіs Natrіі bromіdі (1:5) 25ml V total =180ml Prepared: Checked:

12 Rp: Kalіі bromіdі Natrіі bromіdі aa 2,0 Aquae Menthae ad 200ml Mіsсe. Da. Sіgna. По 1 столовій ложці 3 рази в день.  In the case, when of the recipe as a solvent prescribed flavored water is allowed to use concentrated solutions of powdery substances and Capacity factor of increased do not use.  Technology: measure off 200ml of water mint and dissolve in it 2.0 sodium bromide and potassium bromide, and then filtered in the bottle for dispensing.  WPC Date № prescription Aquae Menthae 200ml Kalіі bromіdі 2,0 Natrіі bromіdі 2,0 V tot. = 200ml Prepared: Checked:


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