1. Histology Laboratories James D. Jamieson, MD/PhD
Molecules to Systems
2003
Compiled by
James D. Jamieson, MD/PhD
Thomas L. Lentz, MD
No part of this image collection may be distributed outside of the Yale University Intranet.

2. Acknowledgements Sources of Micrographs, Diagrams and Figures
Alberts, B. et al. Molecular Biology of the Cell. 4th Edition, Garland Science, New York, 2002.
Gartner, L. P. and Hiatt, J. L. Color Atlas of Histology, Williams & Wilkins, Baltimore, 1994.
Kerr, J. B. Atlas of Functional Histology. Mosby, London, 1999.
Kessel, R. G. and Kardon, R. H. Tissues and Organs: a text-atlas of scanning electron microscopy. W. H. Freeman, San Francisco, 1979.
Lentz, T. L. Cell Fine Structure. W. B. Saunders, Philadelphia, 1971.
Lodish, H. et al. Molecular Cell Biology. W. H. Freeman, New York,
Mizoguti, H. Color Slide Atlas of Histology. Nihon Shashin Shinbunsha, Tokyo.
Young, B. and Heath, J. W. Wheater’s Functional Histology. Churchill Livingstone, Edinburgh, 2000.
Micrographs taken by George Palade, Marilyn Farquhar, James D. Jamieson, Nicolai Simionescu, Maya Simionescu, David Castle, Thomas L. Lentz.
Web Resources
Cushing Library Educational Software/Cell Biology/Several Histology Resources

3. Nervous System Laboratory

4. Spinal Cord

5. GM
Dorsal root ganglia WM
V root
Spinal Cord; Transverse Section

6. Motor Neurons
Ventral Horn
Dendrite
Nissl substance = RER
Axon hillock

7. Sensory Ganglia
Dorsal Root

8. Peripheral Nerves

9. Endoneurium
Perineurium
Epineurium
Epineurium
Epineurium
Epineurium
Myelinated Nerve: XS

10. Unmyelinated Nerve: XS

11. Axons
Schwann cell nuclei
Peripheral Nerve: LS

12. Myelin NR
Axon
Myelin Sheath: Node of Ranvier

13. A A
Schwann cell cyto.
Unmyelinated Axon; LS

14. Schwann cell nucleus A A
Myelinated Axons

15. Cerebral Cortex

16. Cerebral cortex
Cerebellum

17. Horizontal Section

18. GM WM
Cerebral Cortex

19. Nerve cell body
Axons
Glial cells
Grey Matter

20. Astrocytes
Neuroglia

21. Cerebellum

23. Molecular layer
Purkinje cell layer
Granular layer
Cerebellum

24. Cerebellum: Purkinje CellsML
Dendrites PC GL

25. Some pathology to think about.

26. Alzheimer’s Brain: Gross

27. Alzheimer’s Brain, H&E
Do you see anything different in the cytoplasm of the neurons? What might this do to them?

28. Normal Brain Compared to Brain from Parkinson’s Patient, H&E
Which section is from the normal brain and why do you conclude this?

29. Brain From Stroke Patient

30. Section from Brain of Stroke victim

31. The results of anoxia. Which cells are affected?

32. Brain from Infant with Tay-Sach’s Disease
What organelles in these cells are defective and how does the morphology reflect this?

33. Cerebrum from Patient with Creutzfeldt-Jacob Disease.
Note “holes” in cortex resulting from prion amyloid deposits. Human form of “mad cow disease: bovine spongioform encephalopathy”.