1. CNS Sequence
CNS Histology
March 9, 2009

2. Spinal cord Dorsal horns: Interneurons Ventral horns: Motor neurons
Lateral horns:
Sympathetic neurons Parasympathetic (S2-4) neurons
DRG: Sensory (pseudounipolar) neurons
Autonomic ganglia: Post ganglionic neurons with unmyelinated axons.
Sympathetic: paravertebral ganglia
Parasympathetic: In organs

3. 66a Thoracic Spinal Cord Dorsal median sulcus Dorsal horn
Dorsal nucleus of Clarke
Lateral horn
Ventral horn
Ventral median fissure

4. (preganglionic sympathetic neurons of intermediolateral cell column)
66a Thoracic Spinal Cord
Neurons in Lateral Horn
Neurons in Ventral Horn
(preganglionic sympathetic neurons of intermediolateral cell column)
(motor neurons)

5. Thoracic cord dorsal horn: spinocerebellar neurons of Clarke’s nucleus
(relay proprioceptive input up to cerebellar cortex:
e.g. from muscle spindle  DRG  spinocerebellar neuron  cerebellum)

6. Thoracic cord: dorsal horn neurons (interneurons)
short projections to other neurons at same level or nearby spinal level

7. #65-1N Spinal cord and DRG Dorsal horn Lateral horn Ventral horn
Dorsal root ganglion (DRG)

8. 65-1N Motor neurons, glial cells and neuropil

9. Dorsal root ganglion cells

10. Motor and Sensory Neurons (Multipolar) (Pseudounipolar)

11. Brain Cerebrum Cerebellum 3rd ventricle 4th ventricle Pons
Sulcus (sulci) Gyrus (gyri)
3rd ventricle
Cerebellum
4th ventricle
Pons
Medulla oblongata

12. Cerebrum and Cerebellum77

13. #77 Cerebellum #76b Cerebrum
C: Cortex of gray matter W: White matter C C C W W W

14. #77 Cerebellum
Cortex
White matter

15. #77 Cerebellum ML GL WM
Purkinje neurons (cells)

16. #77a Cerebellar Cotex

17. #76 Cerebrum
White matter
Cortex of gray matter

18. #76
Cerebral cortex
Ross and Pawlina, p.311

19. C C Cerebellum Cerebrum W W C: Cortex of gray matter W: White matter
Purkinje cells (neurons) C C
Pyramidal cells (neurons) W W

20. #NP004N Hippocampal region CA: Cornus ammonis
ependymal cells of choroid plexus (cuboidal, eosinophilic: produce CSF)
choroid plexus
CA3
CA2
“typical” ependymal cells (columnar,
lining cells)
Hippocampus
CA4 (hilus)
Dentate gyrus
CA1

21. 3 layers of Hippocampal region (CA1-CA3)
Polymorphic layer (nerve fibers, interneuron cell bodies)
Pyramidal cell layer
Molecular layer (dendrites of pyramidal cells)
Pyramidal cells

22. 3 layers of Dentate gyrus
Molecular layer
Molecular layer (dendrites of granule cells)
Granule cell layer (neurons)
Polymorphic layer
Polymorphic layer (interneurons)

23. #74 Sympathetic ganglion cells #75 Parasympathetic ganglion cells
Seminal vesicle

24. Sensory and Autonomic Neurons (DRG) (Parasympatheitc)