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Supplementary Figure S1 Percentage of peaks from Trf1 +/+ p53 -/- -Cre vs Trf1  /  p53 -/- -Cre comparison that are located in non subtelomeric and subtelomeric.

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Presentation on theme: "Supplementary Figure S1 Percentage of peaks from Trf1 +/+ p53 -/- -Cre vs Trf1  /  p53 -/- -Cre comparison that are located in non subtelomeric and subtelomeric."— Presentation transcript:

1 Supplementary Figure S1 Percentage of peaks from Trf1 +/+ p53 -/- -Cre vs Trf1  /  p53 -/- -Cre comparison that are located in non subtelomeric and subtelomeric regions (-3Mbp from telomeres). Note that there is no enrichment in peaks in subtelomeres comparing with the random average of enrichment in the rest of the genome. The chromosomes with higher percentage of peaks in S regions are 4 and 8.

2 B A Supplementary Figure S2 Distribution of TRF1 peaks in the Trf1 +/+ p53 -/- -Cre vs Trf1  /  p53 -/- -Cre comparison. (A) Distance from genes Transcription Start Sites (TSS). Note that most of the peaks are  10kbp from the genes TSS. (B) Distribution of peaks distribution from those that mapped inside a gene. Note that 88.4% of the peaks are intronic. Distance from TSS 0 5 10 15 20 25  -100kb -100kb- -10kb -10kb- -5kb -5kb- -3kb -3kb - -1kb-1kb – 0kb 0kb – 1kb 1kb – 3kb3kb – 5kb 5kb - 10kb 10kb - 100kb  100kb Binding sites (%) % of Peaks overlapping gene features

3 Supplementary Figure S3 Percentage of peaks from the Terc -/- G3 vs wild-type comparison that are located in non subtelomeric and subtelomeric regions (-3Mbp from telomeres). There is no enrichment in peaks in subtelomeres comparing with the random average of enrichment in any other region in the genome.

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