1. Department of Pharmacology Overview 2007-2008 Heidi E. Hamm, Ph.D. Earl W. Sutherland, Jr. Professor of Pharmacology Chair, Department of Pharmacology

2. Pharmacology Faculty PHARMACOLOGY Neuroscience Blakely Emeson Levitt Gurevich Shieh Stanwood Konradi Current search Synaptic electro- physiologist Drug Discovery Conn Forster Weaver Lindsley Future search DMPK with Clin Pharm Clinical Pharmacology Roberts Brash Roden Oates Brown Schneider Knollman Mundy Davies Structural Biology Gurevich Hamm Iverson Spiller Systems Biology Chung Brown Hamm Forster Receptors & Signal Transduction Hamm Sanders-Bush Conn Gurevich Brown Barnett Wadzinski

3. Pharmacology Recruitment 2007 Sean Davies 2007 Sean Davies 2008Christine Konradi 2008Christine Konradi Current Recruitment: neuroscience – synaptic electrophysiologist Current Recruitment: neuroscience – synaptic electrophysiologist Targets of opportunity: Jon Schoenecker Targets of opportunity: Jon Schoenecker Ana Carneiro Carrie Jones Future Recruitments: signal transduction Future Recruitments: signal transduction cancer pharmacology drug disposition systems biology

4. Our New Faculty Recruits Sean Davies studies the lipid products of oxidative stress, the isoketals Sean Davies studies the lipid products of oxidative stress, the isoketals He is a joint recruit with Clinical Pharmacology He is a joint recruit with Clinical Pharmacology He recently received the 2007 NIH Director’s New Innovator Award to develop better long-term treatment strategies for chronic diseases using probiotic bacteria engineered to produce therapeutic compounds. He recently received the 2007 NIH Director’s New Innovator Award to develop better long-term treatment strategies for chronic diseases using probiotic bacteria engineered to produce therapeutic compounds.

5. Our New Faculty Recruits Christine Konradi is a new Faculty Member in Pharmacology – she joined us from the Psychiatry Department Christine Konradi is a new Faculty Member in Pharmacology – she joined us from the Psychiatry Department She trained in the Univ. of Vienna, the Univ. of Wurzburg, Univ. of Medicine and Dentistry of New Jersey, and the Mass General Hospital, Harvard Med. School. She trained in the Univ. of Vienna, the Univ. of Wurzburg, Univ. of Medicine and Dentistry of New Jersey, and the Mass General Hospital, Harvard Med. School. Christine works on the role of psychostimulants in gene regulation in psychiatric disorders She has two R01 grants

6. How are we doing? Reputation Reputation Citations Citations NIH funding NIH funding National Responsibilities & Honors National Responsibilities & Honors Leadership roles Leadership roles

7. Pharmacology Funding 1998 - 2008 We’ve had an incredible year!

8. Pharmacology Funding with Drug Discovery Highlighted

9. Ratio of $ Awarded to Development $ Spent (Average ROI is $8 awarded to every $1 spent in development)

10. New Grants

11. 2007-8: Our Faculty Have Obtained National Grants and Awards Craig Lindsley is PI on a MLPCN Chemistry Center Grant for $18M! This is one of only two in the country. Craig Lindsley is PI on a MLPCN Chemistry Center Grant for $18M! This is one of only two in the country. He also has 2 new R01s He also has 2 new R01s

12. National Grants and Awards Jeff Conn has received large grants from the Michael J. Fox Foundation for Parkinson’s Research and from Seaside Therapeutics for studies of Fragile-X Syndrome Jeff Conn has received large grants from the Michael J. Fox Foundation for Parkinson’s Research and from Seaside Therapeutics for studies of Fragile-X Syndrome He also has 5 R01 grants He also has 5 R01 grants

13. National Grants and Awards Randy Blakely received a NIMH Conte Center grant on Genes Controlling Assembly and Function of Serotonin Systems. Participants include Elaine Sanders-Bush, Pat Levitt, Ron Emeson, Doug McMahon and Evan Deneris Randy Blakely received a NIMH Conte Center grant on Genes Controlling Assembly and Function of Serotonin Systems. Participants include Elaine Sanders-Bush, Pat Levitt, Ron Emeson, Doug McMahon and Evan Deneris Randy also has a R37 MERIT award, a R01 grant, and a PPG on Presynaptic Choline Transporters, as well as a training grant Randy also has a R37 MERIT award, a R01 grant, and a PPG on Presynaptic Choline Transporters, as well as a training grant

14. National Grants and Awards Heidi Hamm is part of a Specialized Center of Clinically Oriented Research (SCCOR) on Thrombosis from NHLBI to study Thrombin Signaling in Platelets Heidi Hamm is part of a Specialized Center of Clinically Oriented Research (SCCOR) on Thrombosis from NHLBI to study Thrombin Signaling in Platelets She also has 3 R01s She also has 3 R01s

15. National Grants and Awards Alex Brown received a new “Systems Biology of Infectious Disease” Grant to study influenza virus interaction with its host, with Alan Aderem of the Institute for Systems Biology Alex Brown received a new “Systems Biology of Infectious Disease” Grant to study influenza virus interaction with its host, with Alan Aderem of the Institute for Systems Biology He also received the renewal of the Lipid MAPS Glue Grant He also received the renewal of the Lipid MAPS Glue Grant

16. National Grants and Awards Vsevolod Gurevich received a new grant from NIGMS entitled “Conformational regulation of arrestin-mediated signaling” Vsevolod Gurevich received a new grant from NIGMS entitled “Conformational regulation of arrestin-mediated signaling” He also has two other R01 grants He also has two other R01 grants

17. National Grants and Awards Joey Barnett is a part of the Systems-based Consortium for Organ Design and Engineering (SysCODE) Joey Barnett is a part of the Systems-based Consortium for Organ Design and Engineering (SysCODE) He also has an R01 and an AHA grant, as well as two training grants He also has an R01 and an AHA grant, as well as two training grants

18. Brian Wadzinski – renewed his NIGMS R01 grant on protein kinase/PP2A complexes Brian Wadzinski – renewed his NIGMS R01 grant on protein kinase/PP2A complexes He also has another R01 grant He also has another R01 grant Eugenia Gurevich received a Michael J. Fox Foundation Grant Eugenia Gurevich received a Michael J. Fox Foundation Grant National Grants and Awards

19. Tony Forster received a Pilot Grant from the Vanderbilt Diabetes Center Tony Forster received a Pilot Grant from the Vanderbilt Diabetes Center He also has an R01 and an ACS Research Scholar grant He also has an R01 and an ACS Research Scholar grant

20. National Grants and Awards Tina Iverson received a NARSAD award on “Allosteric Nucleotide Exchange in G protein  subunits” Tina Iverson received a NARSAD award on “Allosteric Nucleotide Exchange in G protein  subunits” She also has an R01 grant and a VICB pilot grant She also has an R01 grant and a VICB pilot grant

21. National Awards Randy Blakely – 2008 ASPET Julius Axelrod Award; 2008 ASPET- Astellas Award in Translational Pharmacology Randy Blakely – 2008 ASPET Julius Axelrod Award; 2008 ASPET- Astellas Award in Translational Pharmacology Jeff Conn -- PhARMA Foundation Award for Excellence in Pharmacology and Toxicology Jeff Conn -- PhARMA Foundation Award for Excellence in Pharmacology and Toxicology

22. National Awards Dan Roden -- 2008 Rawls Palmer Award for Progress in Medicine, American Society for Clinical Pharmacology and Therapeutics Dan Roden -- 2008 Rawls Palmer Award for Progress in Medicine, American Society for Clinical Pharmacology and Therapeutics Joey Barnett -- AHA Southeast Affiliate Science Integration Award Joey Barnett -- AHA Southeast Affiliate Science Integration Award

23. Our Faculty are Distinguished Leaders Nationally MERIT awards: Randy Blakely, Elaine Sanders-Bush, Jack Roberts MERIT awards: Randy Blakely, Elaine Sanders-Bush, Jack Roberts Editor of Molecular Pharmacology, Jeff Conn Editor of Molecular Pharmacology, Jeff Conn Associate Editors of Molecular Pharmacology, Alex Brown, Randy Blakely, Al George Associate Editors of Molecular Pharmacology, Alex Brown, Randy Blakely, Al George Heidi Hamm NIH Peer Review Advisory Committee, Heidi Hamm HHMI Review Board, Heidi Hamm HHMI Review Board, Heidi Hamm President, American Society for Biochemistry & Molecular Biology Heidi Hamm President, American Society for Biochemistry & Molecular Biology Heidi Hamm

24. Our Faculty are Distinguished Leaders Nationally, cont’d Pat Levitt – NINDS Strategic Plan Committee; Chair, High Risk/High Impact Program Committee, Autism Speaks Foundation; NIMH Blue Ribbon Panel on Intramural Research Programs Pat Levitt – NINDS Strategic Plan Committee; Chair, High Risk/High Impact Program Committee, Autism Speaks Foundation; NIMH Blue Ribbon Panel on Intramural Research Programs Joey Barnett -- co-chair April 2008: Pharmacology Education for the Next 100 Years, San Diego, CA; Chair, American Heart Association Greater Southeast Affiliate Research Committee Joey Barnett -- co-chair April 2008: Pharmacology Education for the Next 100 Years, San Diego, CA; Chair, American Heart Association Greater Southeast Affiliate Research Committee Alex Brown, Organizer/Chair for FASEB meeting on Phospholipases, July 2008 Alex Brown, Organizer/Chair for FASEB meeting on Phospholipases, July 2008

25. Our Faculty are Distinguished Leaders Nationally, cont’d Heidi Hamm -- Member, FASEB Science Policy Committee Peer Review Subcommittee; Board Advisor, FASEB Excellence in Science Awards Committee, 2007-08; Member, AAMC Panel on Safe and Effective Prescribing Practices Heidi Hamm -- Member, FASEB Science Policy Committee Peer Review Subcommittee; Board Advisor, FASEB Excellence in Science Awards Committee, 2007-08; Member, AAMC Panel on Safe and Effective Prescribing Practices Jeff Conn: Chair, Division of Neuropharmacology, ASPET; Scientific advisory board member, Stanley Center for Psychiatric Research, Broad Institute; Technical Evaluation Panel, NIMH Program Review Jeff Conn: Chair, Division of Neuropharmacology, ASPET; Scientific advisory board member, Stanley Center for Psychiatric Research, Broad Institute; Technical Evaluation Panel, NIMH Program Review

26. Our Faculty Receive Kudos at home Jeff Conn – named Lee E. Limbird Professor of Pharmacology Jeff Conn – named Lee E. Limbird Professor of Pharmacology Nancy Brown - 2008 Elaine Sanders-Bush Faculty Award for Mentoring Nancy Brown - 2008 Elaine Sanders-Bush Faculty Award for Mentoring

27. Our Faculty Receive Kudos at Home Joey Barnett was elected to the Vanderbilt Academy for Excellence in Teaching Joey Barnett was elected to the Vanderbilt Academy for Excellence in Teaching

28. Our Faculty are Campus Leaders Randy Blakely - Director, Center for Molecular Neuroscience, Director, Vanderbilt/NIMH Silvio O. Conte Center for Neuroscience Research Randy Blakely - Director, Center for Molecular Neuroscience, Director, Vanderbilt/NIMH Silvio O. Conte Center for Neuroscience Research Pat Levitt – Director, Kennedy Center Pat Levitt – Director, Kennedy Center Jeff Conn - Director, Program in Drug Discovery, Director, Program in Translational Neuropharmacology Jeff Conn - Director, Program in Drug Discovery, Director, Program in Translational Neuropharmacology Dan Roden - Director, Oates Institute of Therapeutic Discovery, Asst. Vice-Chancellor for Personalized Medicine, Principal Investigator, Vanderbilt DNA Database Dan Roden - Director, Oates Institute of Therapeutic Discovery, Asst. Vice-Chancellor for Personalized Medicine, Principal Investigator, Vanderbilt DNA Database Jack Roberts – Faculty Senate Vice Chair-Elect Jack Roberts – Faculty Senate Vice Chair-Elect

29. Our Faculty are Campus Leaders, Continued Nancy Brown - Associate Dean for Clinical and Translational Scientist Development, Director, Vanderbilt (K12) Clinical Research Scholars Program Nancy Brown - Associate Dean for Clinical and Translational Scientist Development, Director, Vanderbilt (K12) Clinical Research Scholars Program Heidi Hamm - Internal Advisory Board, Vanderbilt University Vanderbilt Institute for Clinical and Translational Research, CTSA; Medical Scientist Training Program Faculty Advisory Committee Heidi Hamm - Internal Advisory Board, Vanderbilt University Vanderbilt Institute for Clinical and Translational Research, CTSA; Medical Scientist Training Program Faculty Advisory Committee Ron Emeson – Chair, Institutional Animal Care and Use Committee; University Faculty Senate Academic Programs and Services Committee Ron Emeson – Chair, Institutional Animal Care and Use Committee; University Faculty Senate Academic Programs and Services Committee Tina Iverson serves on the Center for Structural Biology Executive Committee, as well as the Chemical Biology Interface Training Grant Executive Committee Tina Iverson serves on the Center for Structural Biology Executive Committee, as well as the Chemical Biology Interface Training Grant Executive Committee Gregg Stanwood is Associate Director, Vanderbilt Mouse Neurobehavioral Core Gregg Stanwood is Associate Director, Vanderbilt Mouse Neurobehavioral Core

30. Study Section Members Full Members Full Members Joey Barnett Randy Blakely Alex Brown Chang Chung Seva Gurevich Ron Emeson Craig Lindsley Christine Konradi Ad-hoc Members Ad-hoc Members Tony Forster

31. We are Highly Cited Vanderbilt ranks # 5 in The Most- Cited Institutions in Pharmacology & Toxicology, 1996-2006 Vanderbilt ranks # 5 in The Most- Cited Institutions in Pharmacology & Toxicology, 1996-2006

32. A New Faculty Scholarly Productivity Index The index uses only objective criteria to calculate the scholarly productivity of individual faculty. The index uses only objective criteria to calculate the scholarly productivity of individual faculty. It rates faculty members' scholarly output at nearly 7,300 doctoral programs around the country. It rates faculty members' scholarly output at nearly 7,300 doctoral programs around the country. The index was devised by Lawrence B. Martin, graduate dean at the State University of New York at Stony Brook. The index was devised by Lawrence B. Martin, graduate dean at the State University of New York at Stony Brook. It uses faculty publications, citations, awards and grants which it obtains from the web. It uses faculty publications, citations, awards and grants which it obtains from the web.

33. In 2007, Vanderbilt Pharmacology Ranks # 6 in the Country Use of the objective criteria of faculty publications, citations, awards and grants makes clear how strong our faculty are. Use of the objective criteria of faculty publications, citations, awards and grants makes clear how strong our faculty are. Main difference this year is # of faculty they found; 100 this year, 45 last year Main difference this year is # of faculty they found; 100 this year, 45 last year

34. Goodbye, we’ll miss you… Pat Levitt - Director, Vanderbilt Kennedy Center; will be moving in June 2009 to become the Director of the Zilkha Neurogenetic Institute, Chair of Cell and Neurobiology Pat Levitt - Director, Vanderbilt Kennedy Center; will be moving in June 2009 to become the Director of the Zilkha Neurogenetic Institute, Chair of Cell and Neurobiology

35. Goodbye, we’ll miss you… Lou DeFelice has gone to Virginia Commonwealth University to be Director of Graduate Studies in Physiology and Biophysics and Assistant Dean for Graduate Education Lou DeFelice has gone to Virginia Commonwealth University to be Director of Graduate Studies in Physiology and Biophysics and Assistant Dean for Graduate Education

36. Our Challenges Managing fast growth – puts stress on faculty, administration, space Managing fast growth – puts stress on faculty, administration, space Funding in a flat NIH environment – faculty need to be ever more adventuresome about finding funding; bridge funding is SO appreciated! Funding in a flat NIH environment – faculty need to be ever more adventuresome about finding funding; bridge funding is SO appreciated! Economic crisis affects us all, individually, the department, the institution. Economic crisis affects us all, individually, the department, the institution.

37. Pharmacology Administrative Headcount