1. بسم الله الرحمن الرحیم

2. A 74 Y/O female with large right breast mass measured 5.5 x 4.5 x 4 cm.

15. Comedocarcinoma of the breast with invasion?

19. Clinging Ductal Carcinoma in situ( Carcinoma ): - Characterized by one or two cell larger confined to the periphery of the involved spaces. - Two histologic distinct lesions :

20. A: 1. High grade nuclei, 2. Central necrosis may be evident 3. Such lesions are examples of poorly differentiated DCIS.

21. B: 1. Smaller and more uniform cells, with low grade nuclei 2. Characteristic of low grade DCIS. 3. Cells are columnar 4. Not universaly recognized as DCIS. spectrum of ADH ?

22. A 34 Y/O female with cystic lesion of left breast measured 4 x 4 x 3 cm, wall thickness of cyst varied from 0.2 to 1 cm

34. Metaplastic carcinoma

36. Metaplastic Carcinoma Pure squamous Carcinoma - Rare - Usually large (3 to 4 cm ) - Central cystic cavity lined by malignant squamous epithelium - Prognosis : controversial - Acontholysis : poor outcome ( may confused with angiosarcoma )

45. Invasive ductal carcinoma with vascular invasion