1. RECALL: What’s so special about water? It’s a great solvent. It hold’s tons of heat. It has high surface tension. Its less dense as a solid than a liquid. Water, pH and Biological Molecules… The Chemistry of Life!

2. For Polar Molecules, Water Is a Wonderful Solvent Dissolving table salt (sodium chloride)

3. Water Holds Immense Amounts of Heat Forecasts for San Diego and Gallup, 1/11/06 – 1/15/06 Water’s high heat capacity has profound effects on climate and ecology.

4. Water Has High Surface Tension High surface tension allows long water columns to be drawn from roots to leaves – even in a redwood.

5. Water Is Lighter as Solid than as a Liquid This means that ice forms an insulating blanket over water.

6. pH Matters pH is a measure of proton (hydrogen ion or H + ) concentration. In biology, keeping H + levels within a narrow range is critically important. Low pH = lots of H + s, high pH = few H + s.

7. Acids and Bases An acid produces H + A base absorbs H +

8. Carbon’s Cool Because carbon contains 4 electrons in its outer shell, it can pair in many ways with many different atoms in an “attempt” to fill its outer shell. Carbon is the central atom of life…

9. Carbon is the Central Atom of Life. glucose amino acids fat

10. Some Useful Nomenclature Learn to recognize these chemical groups.

11. In Biology, Molecular Shape Matters Its not just chemical formula, it’s the shape of the molecule that lets it do its “job”. Never forget the axiom – structure dictates function. Some major types of biological molecules.

12. Molecules of Life Start with water, add lots of small carbon-containing molecules and ……. How do you build a cell? use these four major classes of biological molecules.

13. Monomers, Polymers and Macromolecules Many biological molecules are macromolecules – huge assemblies of atoms. Biological macromolecules are formed by linking together a set of building blocks (monomers) into long chains (a polymer).

14. Carbohydrates Carbohydrates are used for energy and to create structures. The building blocks for carbohydrates are simple sugars. Three views of glucose, a common simple sugar.

15. Linking Simple Sugars – the First Step to a Polymer A complex carbohydrate is a long-chain polymer made of simple sugars. monosaccharidesa disaccharide

16. Some Familiar and Important Complex Carbohydrates Note the way complex macromolecule are built by linking simple repeating units.

17. Carbohydrates are Central Players in Energy Production and Storage

18. Complex Carbohydrates Are Often Used to Create Structures Cellulose is the most abundant macromolecule on earth – and you’re probably wearing it now.

19. Lipids are Hydrophobic Molecules That Exist In Three Primary Forms Sterol Fat Phospholipid

20. Fats Are Made By Linking Fatty Acid Chains to Glycerol, a Three Carbon Molecule Space-filling model of a fat A fatty acid

21. Molecular Structure of a Fat

22. Fats are Used in Energy Storage and Production

23. The Degree Of Saturation In A Fat Affects Its Physical And Health Properties Where are the double bonds?

24. Cis and Trans Unsaturated Fats all cis polyunsaturated “Good” Omega-3- fatty acids mono- and poly- unsaturated saturated trans “Bad”

25. Sterols Note the four ring structure common to all sterols. Sterols are: 1) essential membrane components and 2) form many hormones.

26. Sterols As Hormones “Designer steroids” are major sporting news where they have been used illegally in track and field, baseball, football and countless other sports. A heavily muscled Linford Christie who was disqualified from international competition after testing positive for a banned steroid.

27. Phospholipids are Building Blocks of Cellular Membranes The hydrophilic head group and hydrophobic tails are the keys to phospholipid function. Phospholipids have a molecular Jekyll and Hyde split personality.

28. Hydrophilic Head Group And Hydrophobic Tails Are The Keys To Phospholipid Function

29. Phospholipids Form Double-Layered Biological Membranes

30. Protein Proteins are THE key elements of life. Remember the principle - structure determines function. Since proteins are the key players of the cell, it follows that protein structure determines cell function.

31. Some of the Diverse Functions of Proteins

32. Proteins are Linear Chains of Linked Amino Acids

33. A Common Thread and a Unique Identity

34. Amino Acids, Peptide Bonds, Polypeptides, Protein Peptide bonds Proteins are linear chains of 20 different building blocks called amino acids. Amino acids are linked by peptide bonds – a form of covalent bond.

35. Proteins are Folded Structures Whose Shape (and therefore function) Depends on Amino Acid Sequence

36. Primary Structure Conformation: Linear structure Molecular Biology: each type of protein has a unique primary structure of amino acids Ex: lysozyme Amino acid substitution: hemoglobin; sickle-cell anemia

37. Secondary Structure Conformation: coils & folds (hydrogen bonds) Alpha Helix: coiling; keratin Pleated Sheet: parallel; silk

38. Tertiary Structure Conformation: irregular contortions from R group bonding √hydrophobic √disulfide bridges √hydrogen bonds √ionic bonds

39. Quaternary Structure Conformation: 2 or more polypeptide chains aggregated into 1 macromolecule √collagen (connective tissue) √hemoglobin

40. Nucleic Acids There are two kinds of nucleic acids, DNA and RNA. Both are involved in the storage and flow of information from gene to gene product. DNA Recently, we’ve learned that RNA also plays important regulatory roles.

41. Nucleotides Are the Monomers That Create Polymers of DNA and RNA

42. Nucleotides fuel the cell and coordinate its metabolism. Nucleotides are Important in Their Own Right ATP, the cell’s primary energy currency.