1. Lesson 2.1.2
Avery

2. The Insulin Glucose Connection
Introduction:
The building blocks for our body are cells
Cells are able to communicate by different molecules that move from cell to cell
The molecules that are used are called proteins
The protein is released from one cell and sent to another cell. They attach at receptors

3. Goals of the Lesson
To differentiate between a credible/non-credible source
Use the internet to research the connection between Insulin and Glucose.
Write a summary on the process of insulin binding to the cell to accept glucose
Using credible sources research key terms and their connection
Research similarities and differences between Type 1 and 2 with regards to how the body uses insulin
Create a 3D model that represents how the body gets glucose into the cell with type one and type two diabetes.

4. Credible Sources
To tell if a website is credible or not use the following chart to check.
Credible
Not Credible
Author
Establishes credibility on the topic (degrees, experience)
No information on the author
Website/Url
A credible website (gov site, university, charity)
People can change the information and give false info (Wiki)
Ad’s
Little to no pop ups or ads
A lot of pop-ups and ads
Date
Has a recent or newer copyright date
Old/out of date,old information
Reference
Has references and additional links
No references

5. Summary of Insulin and Glucose
The digestive system breaks down food that was eaten to simple glucose molecules
Glucose enters the bloodstream and flows through the pancreas
The pancreas releases insulin into the bloodstream
The glucose arrives at the cell but can’t get into the cell without the insulin
The insulin arrives and attaches itself to the insulin receptor on the outside of the cell membrane
The insulin receptor triggers glut4 transporters to travel to the inside of the cell membrane to open up part of the cell membrane for the glucose to come in
Cell can use glucose to make energy

6. Key Terms
Insulin: Hormone produced in the pancreas that is used by the body to let glucose into the cell
Glucose: Sugar that is found in food that the is used by the cells as a form of energy
Beta Cells: Specialized cells in the pancreas that release insulin as blood glucose levels increase
Glut 4 Transporters: Transport protein inside a cell that is triggered by the insulin receptor to attach to the cell membrane and open it up to for the glucose
Insulin Receptor: A receptor that sits on the outside of the membrane and is the place where insulin attaches to release glut4
Blood: In reference to diabetes the blood carries glucose and insulin to different cells and different parts in the body.
Lymph: The lymph in the body can attack insulin causing the body to not get enough glucose into the cells
Cell Membrane: Outer layer of the cell that is semi-permeable and regulates what comes in and goes out of the cell

7. Similarities Between Type 1&2
Is detected in youth
Have similar symptoms
Detected in later years
Body doesn’t produce insulin
Failure to produce proper insulin
Produces insulin that gets rejected by the cells
Insulin injections are used as a mediation
Insulin is a treatment
Can be regulated with healthy exercise and diet

8. 3D Model
Last part of the lesson was to create a 3D moveable model that shows how a person with diabetes’ body’s relationship between insulin and glucose.
The model needs to be simple and easy enough to understand, like you were going to give a presentation to people who were recently diagnosed with type 1 or 2 diabetes.
The presentation must have included all of the key terms and how the work within the body.
It must be easy to understand for people who have no prior knowledge on the disease.