1. Lecture Outline Periods of Prenatal Development –Period of the zygote –Period of the embryo –Period of the fetus Teratogens –General Principles –Cigarette Smoking and Alcohol (examples)

2. Period of the Zygote (or Germinal Period) Lasts about 2 weeks, from conception through implantation Zygote undergoes mitosis (cell duplication) as it travels down the fallopian tube to the uterus By approximately the 4 th day after conception, the zygote has become a blastocyst –Fluid-filled ball of cells

3. Two parts of the blastocyst: Inner cell mass: Cells on the inside of the blastocyst –Will become the embryo Trophoblast: Cells on the outside of the blastocyst –Will develop into tissues that protect and nourish the embryo

4. Implantation of the blastocyst into the uterine wall begins approximately 7 to 9 days post-conception Support structures begin to develop from the trophoblast after implantation

5. Conception and Implantation

6. Support Structures: Amnion: Membrane that encloses the embryo in amniotic fluid –Cushions organism from injury –Helps to keep temperature constant

7. Placenta: Organ that is fed by blood vessels from the mother and from the embryo –Connected to the embryo by the umbilical cord –Allows nutrients and oxygen to reach the organism and waste products and carbon dioxide to be carried away –Provides some protection to the embryo by preventing some substances from reaching the embryo’s bloodstream

8. By 2 weeks post-conception, inner cell mass has differentiated into three layers of cells: –Ectoderm --> nervous system, outer layer of skin, nails, teeth, ears, eyes –Mesoderm-->muscles, skeleton, circulatory system, inner layers of skin –Endoderm-->digestive system, lungs, urinary tract, glands

9. Period of the Embryo Lasts from the 3 rd through the 8 th week post- conception (about 6 weeks)

10. Ectoderm folds over to form a neural tube (primitive spinal cord) –Top of the neural tube swells to form a brain (about 3.5 weeks post-conception) External body structures (e.g., arms, legs) and internal organs (e.g., heart) begin to develop Rapid brain development occurs

11. Period of the Fetus Lasts from the 9th week post-conception until 38 weeks post-conception

12. Period of the Fetus (between approximately 9-12 weeks): –Organs, muscles, and nervous system start to become organized and connected By about 12 weeks, fetus engages in most movements that are present at birth –Exs: kicking, thumb-sucking, grasping, swallowing –Expansion and contraction of lungs (“fetal breathing”)

13. Period of the Fetus (2nd trimester): –Between approximately 16-20 weeks post- conception, mother starts to feel movement of fetus –Fetus can hear internal and external sounds at approximately 18-20 weeks post- conception

14. Period of the Fetus (3 rd trimester): –Fetus triples its weight during the last trimester –Brain growth also continues Cerebral cortex enlarges –Near the end of pregnancy, fetus is awake more often than earlier in pregnancy but still asleep most of the time –Fetal activity level is correlated with infant activity level

15. Teratogen: Any environmental agent that can cause damage during the prenatal period

16. General Principles of Teratogenic Effects: Dose: Larger doses over longer time periods usually have more negative effects Heredity: The genetic makeup of the mother and embryo/fetus influence the effect of a teratogen

17. Timing: Effects of a teratogen vary with the age of the organism at the time of exposure –Sensitive Period: Time during which basic structures are being formed Each major organ system has its own sensitive period –An organ system is most vulnerable to teratogens during its sensitive period

19. Cumulative Risk: Effect of a teratogen may be worse if there are other risk factors present (e.g., poor nutrition, lack of medical care, other teratogens)

20. Cigarette Smoking: Most consistently associated with low birth weight, which is a risk factor for other developmental problems

21. © Allyn & Bacon/Longman 2007 Low Birth Weight and Disabilities

22. Mechanisms (Smoking): Nicotine constricts blood vessels –Reduces blood flow to the uterus and causes placenta to grow abnormally Reduces the transfer of nutrients to the fetus Nicotine raises the concentration of carbon monoxide (and decreases oxygen) in mother’s and fetus’ bloodstreams –Likely to slow fetal growth and may damage CNS

23. Fetus exposed to carcinogens contained in tobacco

24. Alcohol: –Fetal Alcohol Spectrum Disorder (FASD) Refers to harmful effects of prenatal alcohol exposure Includes fetal alcohol syndrome as well as less severe disorders

25. Fetal Alcohol Syndrome: Facial abnormalities Slow physical growth Brain injury –Small head –Impairment in at least three areas of neurological functioning Memory, language/communication, attention span, activity level, planning/reasoning, motor coordination, social skills

26. Figure 2.18 Effects of FAS Siegler, DeLoache and Eisenberg: How Children Develop, Second Edition Copyright © 2006 by Worth Publishers

27. Mechanisms (Alcohol): Interferes with fetal brain development –e.g., reduced brain size, damage to many brain structures Adult’s body uses large quantities of oxygen to metabolize alcohol –Fetus receives less oxygen (needed for cell growth)