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 How effective is taxol  Is there any other alternative  What is the chemical structure of taxol  What the iupac name for taxol.

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Presentation on theme: " How effective is taxol  Is there any other alternative  What is the chemical structure of taxol  What the iupac name for taxol."— Presentation transcript:

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2  How effective is taxol  Is there any other alternative  What is the chemical structure of taxol  What the iupac name for taxol

3  Taxol is effective in the treatment of metastatic breast cancer because it targets the the mitotic spindle and the drug promotes polymerization and stabilization of tubulins to microtubulins.

4  Yes there is!!  Taxotere is another alternative for taxol and is more effective in the treatment of metastatic breast cancer with fewer side effect  Also taxotere is more soluble than taxol.

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6  2α,4α,5β,7β,10β,13α)-4,10-bis(acetyloxy)- 13-{[(2R,3S)- 3-(benzoylamino)-2-hydroxy-3- phenylpropanoyl]oxy}- 1,7-dihydroxy-9-oxo- 5,20-epoxytax-11-en-2-yl benzoate

7  George AO, Pascal VP, Hayley M and Susan BH: Mechanism of taxol resistance to microtubules. Oncogene 2003:22:7280-7295. 2nd November, 2012.  Ringel I, Horwitz SB. Studies with RP 56976 (Taxotere ® ): a semisynthetic analogue of Taxol. J Natl Cancer Inst. 1991; 83:288-291. 2nd November, 2012


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