1. Teaching Students in Faculty of Arts and Science Pathophysiology Mingyao Liu Professor of Surgery Faculty of Medicine, University of Toronto November 21, 2009, Shanghai, China

2. Outline Merge of universities, the bigger the better? University of Toronto Human biology programs Teaching human biology by faculties from Medicine Translational medicine

3. People 58,915 undergraduates 12,287 graduate students International Students: 5,312 undergraduate (9%) 1,753 graduate (15%) 456 post-doctoral fellows 1123 clinical and research fellows Resources Faculty: 2,159 tenure/tenure-stream 5,461 clinical faculty Annual operating budget of $1.8B One of the top 5 research libraries in North America with over 15 million holdings Infrastructure 3 campuses 18 faculties 841 undergraduate programs 520 graduate programs 14 professional Programs This is U of T...

4. Excellence at UofT 24th out of 500 in Shanghai Jiao Tong University Ranking on research intensity 1st in Canada and 19th in North America (2007) Publishes more science research paper than any public university in North America Excellence in disciplines across major spectrum Source: Times Higher Education Supplement, 2008

5. Prodigious Quality AAU: Association of American Universities

6. Medicine and Health Sciences A corridor to 10 major teaching health science centres, the Ontario Agency for Health Protection and Promotion and the MaRS Convergence Centre: UofT ranked sixth in clinical medicine and 14th in life sciences in scientific performance (HEEACT, 2009) 6,835 separate research grants (2007) > $550 million in annual funding 1900 faculty, including 156 Canada Research Chairs and 70 Fellows of the Royal Society of Canada over 5,000 clinical faculty and over 6,000 students in over 8 Faculties and schools Source: Times Higher Education Supplement, 2008

7. Striking Quality Thomson ISI US and Canadian University Indicators, Deluxe and Standard Editions 2007

8. Three Campuses 2006 Enrolment: Mississauga: 9,669 St. George: 50,871 Scarborough: 9,603 Faculty of Arts and Science: over 50,000 undergraduate students

10. Human Biology Programs Environment & Health Genes, Genetics & Biotechnology Global Health Health & Disease Health Care Ethics Human Biology Neuroscience

11. HMB201H - Introduction to Genes, Genetics and Biotechnology HMB202H - Introduction to Health and Disease HMB203H - Introduction to Global Health HMB210H - Scientific Controversies and Misconceptions HMB301H - Biotechnology HMB302H - Vertebrate Histology and Histopathology HMB303H - Global Health and Human Rights HMB304H - Biomedical Visualization HMB306H - Epistemological Ethics in Medicine HMB310H - Laboratory in Neuroscience HMB314H - Laboratory in Human Biology HMB325H - Statistics Applied to Human Biology NEW350H - Selected Topics: AIDS in Africa, Challenges and Successes HMB397H - Scientific Communication

12. HMB402H - Bench-to-bedside: translating lab research into clinical practice HMB422H - Seminar in Health and Disease HMB430H - Trends in Neuroscience HMB434H - Complementary and Alternative Medicine HMB435H - Topics in Molecular Cell Biology HMB436H - Human Fungal Interaction HMB441H - Genetics of Human Disease HMB444H - Human Biology and Human Destiny: Science, Popular Science, and Science Fiction HAJ453H - AIDS: A Global Perspective JEH455H - Current Issues in Environment and Health HMB472H - Exercise Physiology HMB473H - Exercise and Mental Health HMB489H - Advanced Laboratory in Human Biology

13. Full Year Research Projects HMB399Y - Independent Experiential Study Project HMB400Y - Research Project in Neuroscience HMB498Y - Research Project in Global Health HMB499Y - Research Project in Human Biology

14. Computer Science Medicine MARS CCBR Dan MSH UHN HSC St. George Campus & Hospitals

15. HMB402H – Bench-to-bedside: translating lab research to clinical practice Professor John Marshall –Sepsis clinical trials –Inflammation and apoptosis –Student presentations Professor Mingyao Liu –Acute lung injury and lung transplantation –Nanoparticle based drug delivery in treatment of acute lung injury –Student presentations Professor Heather Ross –Incorporating a transplanted heart –Remote ischemic pre-conditioning –Student presentations

16. Acute Lung Injury: from Molecular Mechanism to Nano-Medicine Mingyao Liu, MD, MSc Professor of Surgery, Medicine and Physiology Director, International Research Relations Faculty of Medicine, University of Toronto Senior Scientist Director, Center for Research Education and Training University Health Network Toronto General Research Institute

17. Outline A history of ARDS Conflicts in treatment of ARDS Ventilator-induced lung injury Mechanotransduction Src inhibition as a potential therapy Nano-particle based drug delivery

18. HMB402HIF Bench-to-Bedside: Translating Lab Research into Clinical Practice Module 2-2: Nanotechnology in Lung Injury Instructors: Mingyao Liu, MD, MSc Shan-Yu Fung, BSc, MASc, PhD October 23, 2009

19. Module 2-2 Course Outline Introduction to Nanotechnology –Historical background –What is nanotechnology? –Molecular self-assembly Nanotechnology in medicine –Nanoparticles for drug delivery –Self-assembling peptide based nano-delivery: case studies Nanotechnology in Lung Injury –Nanoparticles for pulmonary delivery –Nano-drug delivery for acute lung injury: case studies

20. Student Presentation Every student chose a paper related to selected subject 10 minutes slides presentation 5 minutes question period Scored by students –Scientific contents –Critical thinking –Presentation (visual, voice, eye contact...)

21. Summary Synergy between Faculty of Medicine and Faculty of Arts and Science Considering the career pathways for students Training the trainees (post-doc and students) Participation, ability and knowledge