1. GCSE Core ScienceHuman Biology Key Words TOXIC, SIDE EFFECTS, THALIDOMIDE

2. GCSE Core ScienceHuman Biology STARTER 1. Which one is not used by white blood cells to protect us against pathogens? AProduction of antibodies to destroy bacteria BSealing of wounds to prevent infection CProduction of antitoxins to counteract poisons released by pathogens DIngestion of pathogens. 2. MRSA is a bacterium that kills around a thousand hospital patients each year. Which one of the following has led to these MRSA infections? AIneffective vaccines BOvercrowding in hospitals CAntibiotic resistance DShortage of hospital equipment 3. Which of the following would not help control the spread of MRSA? AMedical staff having regular health checks BMedical staff washing their hands between seeing patients CVisitors washing their hands as they enter and leave the hospital DCleaning hospitals with antiseptics 4 New drugs are thoroughly trialled and tested to ensure they have certain features that make them good medicines. When tested on human volunteers, it is not possible to keep every control variable constant. So how can researchers make their data reliable? AUse only animals instead of humans in tests. BOnly test people over the age of 65. CUse as large a sample of people as possible. DCalculate the mean age of the people tested.

3. GCSE Core ScienceHuman Biology Objectives By the end of the lesson I will: Know that a new medicine must be effective, safe and be able to be stored for a period of time Know that new medicines are tested in laboratories to see if they are toxic. This testing is often on animalsKnow that new medicines are tested in laboratories to see if they are toxic. This testing is often on animals Know that new medicines are tested on human volunteers to see if they workKnow that new medicines are tested on human volunteers to see if they work Be able to explain the process involved in testing a new medicine Explain why it is important to test new medicationsExplain why it is important to test new medicationsthoroughly Be able to provide a balanced argument for the useBe able to provide a balanced argument for the use of animals in testing new medicines

4. GCSE Core ScienceHuman Biology It costs a lot of money and a lot of time to develop new medicines. New medicines must be tested to see if they are toxic (poisonous) and effective (cure the disease). This occurs in laboratories on animals. Task 1

5. GCSE Core ScienceHuman Biology If these tests are not thorough then a new medicine may have dangerous side effects Thalidomide is a medicine that was widely used in 1950s as a sleeping pill. It also helped to prevent ‘morning sickness’ in pregnant women. It was not tested thoroughly enough before been marketed, women started to give birth to babies with severe limb abnormalities. It is no longer used for pregnant women but it is effective in treating leprosy Task 1

6. GCSE Core ScienceHuman Biology Evaluate the methods used to trial new medicines. Include an historic case. (5 marks) Task 2 GLOSSARYEvaluate: To judge or determine the significance of….

7. GCSE Core ScienceHuman Biology Objectives By the end of the lesson I will: Know that a new medicine must be effective, safe and be able to be stored for a period of time Know that new medicines are tested in laboratories to see if they are toxic. This testing is often on animalsKnow that new medicines are tested in laboratories to see if they are toxic. This testing is often on animals Know that new medicines are tested on human volunteers to see if they workKnow that new medicines are tested on human volunteers to see if they work Be able to explain the process involved in testing a new medicine Explain why it is important to test new medicationsExplain why it is important to test new medicationsthoroughly Be able to provide a balanced argument for the useBe able to provide a balanced argument for the use of animals in testing new medicines