1. Abstract Psychosomatic disorder are group of psychiatric in witch psychological factors play an important role in creating and exacerbating of medical conditions. The most important category of psychosomatic disorders is cardiovascular (CV) and gastrointestinal (GI) diseases. The present study aimed to compare the acceptance of internal experiences in patients with cardiovascular, gastrointestinal and healthy individuals in Isfahan. Therefore, 50 patients with gastrointestinal diseases, 50 patients with cardiovascular that referred to psychosomatic clinics and offices of related physicians and 50 healthy individuals were selected based on convenience sampling method. Action and Acceptance Questionnaire (AAQ-II) were administered in three groups. The data were analyzed by Multivariable Analysis of Variance (MANOVA) and t- test for independent samples. The result showed that there were significant differences in all subscales of AAQ-II between patient groups (GI and CV) and healthy individuals. But there were no significant differences between GI and CV patients. This study showed that denial of internal experience play an important role in disorders, including cardiovascular and gastrointestinal disease. Keywords: Psychosomatic disorder, cardiovascular disease, gastrointestinal disease, Mental disorder, Acceptance of internal experience Introduction Psychosomatic disorder are group of diseases such as cardiovascular (CV) and gastrointestinal (GI) diseases in witch psychological factors play an important role in creating and exacerbating of medical conditions (1). Cardiovascular disease and gastrointestinal disease because of daily concerne and physical symptoms related with the disease avoid more than other people of te stimuli that cause these symptoms.Those who accept their negative experiences and not avoid it less likely stressful experiences in the area of mental health are related damage (2). Methods In this prospective cohort study 50 patients with gastrointestinal diseases, 50 patients with cardiovascular that referred to psychosomatic clinics and offices of related physicians and 50 healthy individuals were selected based on convenience sampling method. Table 1- Mean score and comparison of acceptance of internal experiences in patients with gastrointestinal disease, cardiovascular disease and healthy individuals According to the Tukey test there is significant differences in acceptance of internal experiences between healthy individuals and patients with gastrointestinal and cardiovascular disease (P<0/01). 1)American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (Fifth ed.). Arlington, VA: American Psychiatric Publishing. 2)Shallcross, A. J., Troy, A. S., Boland, M., Mauss, I.B. (2010). Let it be: Accepting negative emotional experiences predicts decreased negative affect and depressive symtoms Behavioral reaserch and therapy, 48,921_929.. The ACBS World Conference 13 In Berlin, Germany Acceptance of internal experiences in gastrointestinal and cardiovascular disease compared to healthy individuals in Isfahan city Mina kavoosi Mina kavoosi 1, Fatemeh Zargar 2 * Corresponding Author: department of clinical psychology, Kashan University of Medical Science, Kashan, IR Iran The ACBS World Conference 13 In Berlin, Germany Acceptance of internal experiences in gastrointestinal and cardiovascular disease compared to healthy individuals in Isfahan city Mina kavoosi Mina kavoosi 1, Fatemeh Zargar 2 * Corresponding Author: department of clinical psychology, Kashan University of Medical Science, Kashan, IR Iran Sig.F Healthy individuals cardiovascular disease gastrointestinal disease 0.035.3731.18±13.3337.12±12.9538.34±12.64 Acceptance of internal experiences