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Medical Imaging Resource Center (MIRC) Clinical Trial Applications

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Presentation on theme: "Medical Imaging Resource Center (MIRC) Clinical Trial Applications"— Presentation transcript:

1 Medical Imaging Resource Center (MIRC) Clinical Trial Applications
Joshua Tan Division of Radiologic Sciences Wake Forest University School of Medicine Departments of Radiology and Biomedical Engineering November 28, RSNA 2005 Chicago, IL

2 Overview Introduction WFUSM MIRC configuration
WFUSM uses MIRC for multi-center clinical trials

3 Introduction MIRC collaboration among RSNA, UPenn, and WFUSM was initiated in early 2004. UPenn and WFUSM MIRC test (WAKEUP) Images sent from WFUSM research MR scanner to WFUSM MIRC to UPenn MIRC RSNA Chris Carr John Perry WFUSM Dr. Jeffrey Carr Dr. Kerry Link Dr. Joseph Maldjian Dr. Peter Santago Bob Ellison Joshua Tan UPenn Dr. Nick Bryan Lisa Desiderio Dengfeng Liu

4 Dedicated research modalities
WFUSM Center for Biomolecular Imaging Dedicated research modalities GE Twin Speed 1.5T MR Scanner GE Sigma Excite 3.0T MR Scanner GE 16-slice Light Speed Pro CT Scanner GE Discovery ST-8 PET/CT Scanner   GE Advance NXi PET Scanner Concord MicroPET Scanner Bruker 7.0T MicroMR Scanner with a 30cm. bore

5 WFUSM MIRC hardware configuration
WFUSM Firewall WFUSM MIRC hardware configuration TeraRecon imaging analysis workstation GE Advantage imaging analysis workstation Remote MIRC FieldCenter Remote Network Internet WFUSM MIRC in DMZ MIRC within WFUSM firewall WFUSM Network WFUSM NAS WFUSM research DICOM server External RAID backup system External Ultra SCSI3 Remote MR Remote CT

6 WFUSM MIRC software configuration
MIRC computer MIRC FieldCenter or MIRC v T26 Tomcat v Java J2SE v 1.4.2_10 SDK WFUSM Network WFUSM research DICOM server External RAID backup system WFUSM NAS Research DICOM server Internet WFUSM MIRC Remote MIRC FieldCenter Remote Network Remote CT Remote MR

7 Application Entity Titles
WFUSM research DICOM server Titan: : port 104 External RAID storage 8 x 250GB hard drives Ultra SCSI-3 Raid5 configuration ~1.7TB of usable space Dell PowerEdge 2800 server Dual 3.0GHz Intel Xeon CPUs 1GB ECC DDR ram 3 x 73GB Ultra 320 SCSI hard drives in a RAID5 configuration Gigabit Network Interface Card Software on PowerEdge Red Hat Linux Version 9.0 WS 3.0 MySQL Database Mallinckrodt CTN software PHP HTML and XML Application Entity Titles WFUSM Network WHIMS CARDIA_XX CARDIA_XV CARDIA_PILOT CARDIA_QC WHI WHI_PILOT WHI_QC CAMPS ADNI CIREN WFUSM NAS

8 Required DICOM elements for CTN DICOM server
(0008, 0018) SOP Instance UID (0008, 0020) Study Date (0008, 0030) Study Time (0008, 0050) Accession Number (0008, 0060) Modality (0008, 0090) Referring Physician Name (0010, 0010) Patient Name (0010, 0020) Patient ID (0010, 0030) Birthdate (0010, 0040) Sex (0020, 000D) Study Instance UID (0020, 000E) Series Instance UID (0020, 0010) Study ID (0020, 0011) Series Number (0020, 0013) Instance Number (0028, 0002) Samples Per Pixel (0028, 0010) Rows (0028, 0011) Columns (0028, 0101) Bits Stored (0028, 0103) Pixel Representation DICOM element must have a value

9 WFUSM DICOM research images Long term storage and archiving
External attached RAID Ultra SCSI-3 Raid5 configuration WFUSM research archiving server Exabyte VXA-2 Autoloader (1 x 10) Sony external DL/DVD±RW drive Research archiving server VXA-2 Tape (80/160GB) DVD-R (4.7/8.5GB) WFUSM NAS NAS (network attached storage) EMC Fiber attached Raid5+1 configuration WFUSM MIRC receivers External RAID backup system WFUSM Network WFUSM research DICOM server

10 WFUSM MIRC DMZ and B2B VPN connections
DMZ (demilitarized zone) Ports 8080, 8443 (internet) Open on WFUSM MIRC to receive via MIRC software Port 104 (intranet) Only open to the internal WFUSM network on port 104 to DICOM export to WFUSM DICOM research server NAT (network address translation) Internet WFUSM MIRC in DMZ WFUSM Firewall Remote Network Remote MIRC FieldCenter WFUSM Network WFUSM research DICOM server B2B VPN (branch to branch virtual private network) Remote modality can DICOM export directly to WFUSM MIRC Information Services from both locations must collaborate for configuration to properly connect and transfer DICOM images Remote CT Internet MIRC within WFUSM firewall Remote MR

11 MIRC software tools FieldCenter DicomEditor FileSender
Application to receive DICOM images from an imaging modality DICOM export images from remote sites to reading center via internet Anonymize/de-identify/modify DICOM images DicomEditor Modification and correction of DICOM header Powerful anonymization/de-identification tool Batch modifying application FileSender DICOM export corrected images back to workstation/DICOM server DICOM export images from local media and network drives MOD CD-rom/DVD-rom Hard drive Other misc media formats

12 Clinical trials using MIRC
WHIMS Women's Health Initiative Memory Study Import DICOM images CARDIA Year20 Coronary Artery Risk Development in Young Adults Import DICOM images WHI Women's Health Initiative Import DICOM images CAMPS Carotid Atherosclerosis MRI Progression Export DICOM images ADNI Alzheimer's Disease Neuroimaging Initiative Export DICOM images to a pc CIREN (WFUSM internal) Crash Injury Research and Engineering Network Archive and distribute DICOM images

13 CARDIA year20 data flow UIC CT USF CT UAB CT UMN CT Calcium scoring
workstations WFUSM firewall #1 WFUSM MIRC in DMZ Internet Remote Network Remote MIRC FieldCenter Internet WFUSM firewall #1 MIRC within WFUSM firewall WFUSM DICOM research server RAID storage WFUSM firewall #2

14 Remote MIRC FieldCenter
CARDIA year20 data flow UIC/USF to DMZ WFUSM MIRC Remote MIRC FieldCenter Remote Network Internet WFUSM MIRC in DMZ MIRC IN: : port 8443 (ext) : port 104,3333,8443 (int) HTTP import to DICOM export (MIRC IN to Titan) HTTP import on DICOM export from to CARDIA_XX (Titan) MIRC software WFUSM firewall #1 UIC CT USF CT WFUSM DICOM research server Titan: : port 104 AE TITLE: CARDIA_XX RAID storage WFUSM firewall #2

15 MIRC within WFUSM firewall
CARDIA year20 data flow UAB/UMN Branch to Branch VPN to WFUSM Internet WFUSM firewall #1 MIRC within WFUSM firewall Delta: ports 104,3333,3334,3335,3336,8443 DICOM import to HTTP export (CT Scanner to Delta) DICOM import from CT Scanner to (Delta) DICOM import from CT Scanner to (Delta) HTTP export to HTTP export to HTTP import to DICOM export (Delta to Titan) HTTP import on HTTP import on DICOM export from to CARDIA_XX (Titan) DICOM export from to CARDIA_XX (Titan) MIRC software DICOM export UAB CT UMN CT WFUSM DICOM research server Titan: : port 104 AE TITLE: CARDIA_XX RAID storage

16 WHI data flow UIC USF UPMC UMN CDs sent via from 26 Field Centers
Calcium scoring workstations WFUSM firewall #1 WFUSM MIRC in DMZ Internet Remote Network Remote MIRC FieldCenter Loaded on WFUSM MIRC receiver WFUSM MIRC receiver FileSender WFUSM DICOM research server RAID storage WFUSM firewall #2

17 Remote MIRC FieldCenter
WHI fieldcenter data flow UAB/UIC/UMN/UPMC/USF to DMZ WFUSM MIRC Remote MIRC FieldCenter Remote Network Internet WFUSM MIRC in DMZ MIRC IN: : port 8443 (ext) : port 104,3334,8443 (int) HTTP import to DICOM export (MIRC IN to Titan) HTTP import on DICOM export from to WHI (Titan) MIRC software WFUSM FIREWALL #1 UIC CT UMN CT UPMC CT USF CT WFUSM DICOM research server Titan: : port 104 AE TITLE: WHI RAID storage WFUSM FIREWALL #2

18 MIRC with WFUSM firewall
WHI data flow CD/DICOM EXPORT to WFUSM RECEIVER WFUSM Network FileSender MIRC with WFUSM firewall Delta: : ports 104,3337,3338,8443 DICOM import to HTTP export (CD to Delta) DICOM import from CD to (Delta) HTTP export to HTTP import to DICOM export (Delta to Titan) HTTP import on DICOM export from to WHI (Titan) MIRC software CDs sent via from 26 Field Centers to WFUSM WFUSM DICOM research server Titan: : port 104 AE TITLE: WHI RAID storage

19 University of Washington
CAMPS/ADNI/CIREN data flow WFUSM modality to WFUSM MIRC OUT Internet HTTP export DICOM send WFUSM MIRC OUT WFUSM Network WFUSM CT CIREN WFUSM (internal) CAMPS MIRC University of Washington ADNI website UCLA WFUSM MR

20 MIRC software summary Secure DICOM image transfer via the Internet
Stable Open-source Multi-faceted and versatile De-identification and modification features Technicians “love” to use the MIRC software Easy to configure and use Web-based interface for effortless examination of received images In conclusion

21 Questions or comments?

22 Special Thanks to: John Perry (RSNA) Peter Santago, Ph.D. (WFUSM)
J. Jeffrey Carr, M.D., M.S. (WFUSM) Kerry M. Link, M.D. (WFUSM) Bob Ellison (WFUSM) Nick Bryan, M.D., Ph.D. (UPenn) Lisa Desiderio (UPenn) DengFeng Liu (UPenn) Steve Moore (Mallinckrodt) Acknowledgements: Wake Forest University School of Medicine (Radiology and Biomedical Engineering) Wake Forest University Health Sciences University of Pennsylvania Winston-Salem State University

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