1. Biotech hotbed

2. Uppsala BIO Uppsala BIO is an initiative from the local biotech industry, the two universities in Uppsala and regional development bodies. Its aim is to promote the long-term growth of the biotech sector in the region.

3. Why hotbed?

4. Look at what grows here Successful start-ups Fast-movers Global-leaders

5. Olink – a new biotech start-up Olink, a venture between university researchers and local entrepreneurs, has developed a new method of analyzing proteins. In one format, the technology uses high-precision micro- structures made via polymer replication. Jonas Jarvius, Ph.D. student, Uppsala University, and co-founder of Olink

6. Olink – success factors Outstanding research facilities (Rudbeck and Ångström labs) Close proximity to local companies (e.g. Åmic) Support from Uppsala BIO-X plus local entrepreneurs Uppsala’s track record of commercializing biotech innovation Followed a well-proven pathway (innovation, patent, proof-of-principle, market need, business plan, initial financing)

7. NeoPharma – fast track to market and sales NeoPharma’s first pharmaceutical, Duodopa ®, has been approved for the treatment of Parkinson’s disease in Sweden and nine other European countries. Ulf Rosén, CEO, NeoPharma Christer Nyström, Professor, Uppsala University

8. NeoPharma – success factors Access to staff and management with solid experience from the industry Pharmaceutical research at the university’s Department of Pharmacy Hospital staff and researchers coordinate clinical evaluation with NeoPharma (principle investigator at the hospital) Close proximity to Swedish Medical Products Agency (MPA) MPA acts as reference member state for marketing authorization in EU within the framework of the Mutual Recognition Procedure

9. Q-Med – world-leader in facial esthetics. Growing force in medical implants. RESTYLANE™ products dominate the world market for filling out lips, wrinkles and folds. DEFLUX™ and ZUIDEX™ enjoy increasing success in treating uro- gynecological disorders. Bengt Ågerup, founder and CEO, Q-Med

10. Q-Med – success factors Corporate HQ exercises complete global responsibility One center for business strategy, R&D, clinical research, product manufacture, marketing and sales Skilled personnel available in the region – ‘from people who understand production to those who know how to sell’ In-house ‘business school’ promotes individual development International location

11. National perspective

13. Sweden’s business climate Wages among the lowest in Europe, especially for scientists Corporate tax (28%) is the continent’s next lowest Dividends from foreign subsidiaries not subject to Swedish taxation Deregulated society and infrastructure Recognized success in high-tech industrial ventures People work across company and organizational borders Source: Invest in Sweden Agency Biotechnology Report, 2002.

14. Powerful force in biotechnology Europe’s fourth largest biotech industry (biggest in relation to population/GDP) Best climate for biotech research and innovation plus the highest quality workforce* Fruitful collaboration between industry, universities and public healthcare Academic researchers retain commercial rights to their discoveries Support from experienced life science venture capitalists Centralized public health system with unique medical and genetic records Source: Invest in Sweden Agency Biotechnology Report, 2002. *Cap Gemini Ernst & Young.

15. European biotech industry 2003 European companies per country Source: Ernst & Young

16. Uppsala’s strengths in biotechnology

17. Uppsala has been described as the world’s ‘most biotech- concentrated city’.

19. Unbroken tradition of scientific achievement CenturyScientistAchievementNobel prize 18th O. RudbeckThe lymphatic system 18th C. LinnæusSystema Naturæ classification 18th A. CelciusThermometric scale (°C) 18thJ.J. BerzeliusChemical elements (Se, Th, Si, Ti, Z) 19th A. J. Ångström Modern spectroscopy (Å unit) 19-20thM. SiegbahnX-ray spectroscopy 19-20thT. SvedbergUltracentrifuge 20th A. TiseliusElectrophoresis 20th K. SiegbahnElectron spectroscopy 20thJ.Porath, P. FlodinGel filtration 20thG. Johansson,Immunoglobulin E H. Bennich, L. Wide C. Linnæus T. Svedberg A. Tiselius

20. IgE Pharmacia Diagnostics 204 MUSD Dextran Pharmacia Biotech  Amersham Biosciences  GE Healthcare 10 000 MUSD NeoPharma 3 MUSD ElectrophoresisFunction of Hyaluronic acid 2000 Duodopa 19601940 Personal Chemistry 14 MUSD Microwave synthesis Pyrosequencing 13 MUSD Pyrosequencing SPR Biosensors Unrivalled track-record of commercial success Biacore 67 MUSD Q-Med 78 MUSD Biotage (Personal Chemistry and Pyrosequencing) 1980 Turnover for 2003 AMO Uppsala 114 MUSD

21. The region for your next research, investment or business venture

22. The competence to develop biotechnology More than half of Sweden’s biotech firms in the 70-kilometer Uppsala – Stockholm corridor Uppsala University, the University Hospital and the Swedish University of Agricultural Sciences in the north Karolinska Institute (KI), Stockholm University and the Royal Institute of Technology (KTH) in the south Almost 10% of Uppsala’s workforce employed in biotech-related businesses

23. Tools for Life Science Employees: Approx. 1,500 in privately-owned industries in Uppsala Speciality: Drug discovery systems, medical diagnostics, protein separations

24. Pharmaceuticals and biomedical devices Employees: Approx. 1,800 in privately- owned industries in Uppsala Speciality: Improved drug delivery is a strong niche

25. Diagnostics Employees: Approx. 600 in privately- owned industries in Uppsala Speciality: Both human and veterinary applications

26. The skills to develop biotechnology Broad industrial expertise and business know-how Steady supply of young scientists (many with MBAs) and ideas Leading center for clinical research and trials Home of the Swedish Medical Products Agency, the National Food Administration, the National Veterinary Institute, and the WHO monitoring center for drug side-effects Leading role in Human Proteome Project

27. Uppsala Biotech Sector Documentation and registration Discovery and development Scaling up Production to full GMP Health and medical care Swedish Agricultural University, Uppsala University Biacore, Biotage, GE Healthcare, Gyros, Olink, Quiatech, Uppsala Imanet, Åmic Innoventus, NeoPharma, Orexo, Pharmacia Diagnostics, Q-Med, Resistentia Pharmaceuticals Fresenius Kabi, Pfizer, GIN-laboratory, NeoPharma, Q-Med University Hospital Clinical research University Hospital, Uppsala Clinical Research Center, Centre for Clinical Testing of Foodstuffs Basic research Research tools and platforms Eureda, Quintiles, Statisticon, MPA (also reference member state for authorization in the EU)

28. Leading campus areas Biomedical Centre – chemistry, pharmacology, surface biotechnology, bioinformatics Linnæus Center for Bioinformatics Ångström Laboratory – material sciences, physics, energy, MEMS Center for Mathematics and Information Technology Uppsala Genetics Center – plant biology and forest genetics Veterinary Medicine Center Ludwig Institute for Cancer Research Rudbeck Laboratory – molecular genetics and medicine University Hospital – clinical research, clinical trials Uppsala Clinical Research Center

29. Dag Hammarskjölds väg Linnæus Center for Bioinformatics Ludwig Institute for Cancer Research Ångström Laboratory material sciences, physics, energy, MEMS Center for Mathematics and Information Technology Uppsala Genetics Center plant biology and forest genetics Veterinary Medicine Center University Hospital clinical research, clinical trials Uppsala Clinical Research Center Uppsala BIO SVA National Veterinary Institute Rudbeck Laboratory molecular genetics and medicine MPA Medical Products Agency Biomedical Centre chemistry, pharmacology, surface biotechnology, bioinformatics

30. The will to develop biotechnology Strong culture of academic/industrial and company/company collaboration Open attitude plus world-class biotech and clinical research Post-Pharmacia atmosphere of innovative ideas and business skills Strong networks and close personal ties ‘Teachers’ exemption’ (researchers retain commercial rights to their discoveries)

31. The resources to develop biotechnology ‘Serial entrepreneurs’ with many years experience Uppsala – Stockholm region is the center of Swedish venture capital Clear insight into how to turn innovative ideas into commercial successes Uppsala Innovation Centre, the region’s foremost business incubator, supports the potential in new biotech ideas

32. Complete innovation concept Research and education Start-up companies Growth companies Business plan Business idea Patent Innovation Finance Pre-seeding Seed financing Venture and industrial capital Advice and scouting Entrepreneur skills and training Incubator programs Know-how

33. Investing in Uppsala Invest in Uppsala promotes international expansion and works before, during and after your decision to invest in the region. Free-of-charge services include: Help with all aspects of physical planning Contact with authorities and organizations Locating office and industrial premises Partners and match-making Staff recruitment Housing and accommodation Personalized study visits www. uppsala.se/investinuppsala

34. Sweden ranked 2nd out of 175 countries in the UN 2004 Human Development Index Uppsala excels in lifestyle and living standards Two universities of great breadth and diversity Small town prosperity, cosmopolitan atmosphere Countryside, forests and breathtaking coastal region International location Source: Invest in Uppsala Living and working in Uppsala

35. Stockholm 40 min London 2.5 h Boston 12 h Beijing 8 h Arlanda 30 min

36. Regional/industry challenges Many small biotech companies – how to secure venture capital, make them profitable, and get them to stay following mergers Competence – awaken young persons’ interest in science and management skills Fill the pipeline – establish research fields plus technology transfer Infrastructure – secure transition from university town to science city

37. Regional action plan

38. Promote the long-term growth of biotechnology Research Innovation program Competence and training Communication

39. Growth $ Business Scouting Competence chain Value Marketing Biotech in Uppsala Innovation System Academia Industry Uppsala BIO-X Support for existing companies Incubator Business Lab Entrepreneurs Program Innovation program UniversitiesSchools Entrepreneurs Innovators Industries Further education Regional infrastructure Competence and training Partnering Communication Seminar series Scientific conferences Uppsala BIO-X

40. Research  Uppsala BIO-X – the cross-disciplinary research effort focused on Life Science  Supports ambitious projects based on cutting-edge science with the potential to generate new opportunities for industry  Supplementary funding and resources (mainly for stimulating the formation of multi-disciplinary research teams)

41. Innovation program  Scouting for spin-offs at universities and industry  Incubators focused on commercialization, financing and future viability  Entrepreneurship and Alumni programs  Access to a broad external network of business advisors and financers  Seed-funding for life science projects

42. Competence and training  Promote science programs at schools and universities  Attract young people to science  Encourage more frequent contact between university and industry  Set up management and leadership programs for next generation entrepreneurs  Push the development of housing, transport and schools

43. Communication  Tell the world what happens in Uppsala via website, publications, e-newsletter, congresses, etc.  Arrange international arenas for meetings, networking and partnering  Create a local understanding of and support for biotechnology  Help make the right contacts in industry, research, finance, etc.

44. Vision – one of the world’s top five biotech regions Frontline biotech research Outstanding innovation climate Close academic/industrial collaboration Seasoned serial entrepreneurs Full industrial/business infrastructure International location

45. Contact Uppsala BIO Uppsala BIO Uppsala Science Park Dag Hammarskjölds v. 60 SE-751 83 Uppsala Sweden info@uppsalabio.com www.uppsalabio.com

46. A true biotech hotbed!