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 Congenital abnormalities of the kidneys and urinary tract (CAKUT) are variable, occur in 1 of 500 newborns; predisposing to development of hypertension,

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Presentation on theme: " Congenital abnormalities of the kidneys and urinary tract (CAKUT) are variable, occur in 1 of 500 newborns; predisposing to development of hypertension,"— Presentation transcript:

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2  Congenital abnormalities of the kidneys and urinary tract (CAKUT) are variable, occur in 1 of 500 newborns; predisposing to development of hypertension, cardiovascular disease and end-stage renal failure.  It can affect the kidney(s) alone and/or the lower urinary tract.  Radiological investigation is essential for early diagnosis.

3 ULTRASOUND NORMAL ULTRASOUND NORMAL STOP RENAL PELVIS >10MM OR OTHER ABNORMALI TIES ANATOMIC & FUNCTIONAL STUDY (SCINTIGRAPH Y, IVU) RENAL PELVIS >7MM OR OTHER ABNORMALITI ES VCUG NORMAL ULTRASOUND (3MONTHS) RENAL PELVIS >10MM RENAL PELVIS <10MM STOP ABNORMAL ANATOMIC & FUNCTIONAL STUDY (SCINTIGRAPH Y, IVU) PROTOCOL

4  Ultrasound is commonly the initial investigation study.  If the dilatation of the urinary tract is confirmed, VCUG is performed to identify VUR or other causes of upper tract dilatation.  If VUR is excluded, nuclear diuresis renography is the primary test for identifying obstructed tract anomalies.  IVU or CT scan can also be used to determine the presence of anatomic abnormality.  MR urography can combine superior anatomic and functional information in a single test that does not use ionizing radiation.

5 PLAIN CT SHOWING NORMAL KIDNEYS IN BILATERAL RENAL FOSSA WITH THE ADDITIONAL THIRD KIDNEY IN THE LEFT LOWER LUMBAR REGION. SUPER NUMERARY KIDNEY:-

6  PLAIN CT STUDY SHOWING ABSENCE OF LEFT KIDNEY.  MRI T2 HASTE CORONAL IMAGE SHOWING ABSENCE OF LEFT KIDNEY IN SAME PATIENT. ABSENCE OF LEFT KIDNEY

7  1. PLAIN CT STUDY SHOWING ABSENCE OF RIGHT KIDNEY IN THE RIGHT RENAL FOSSA AND SEEN FUSED WITH THE LEFT KIDNEY.  2. CONTRAST CT STUDY OF THE SAME PATIENT SHOWING RIGHT KIDNEY FUSED WITH THE LEFT KIDNEY IN THE MIDLINE.

8  PLAIN CT STUDY SHOWING ABSENCE OF RIGHT KIDNEY IN THE RIGHT RENAL FOSSA AND SEEN FUSED WITH THE LEFT KIDNEY.

9  ANTENATAL ULTRASOUND EXAMINATION SHOWING SEVERE OLIGOHYDRAMNIOS WITH ENLARGED CYSTIC BOTH FETAL KIDNEYS.  MULTIPLE VARIABLE SIZE PREDOMINANTLY PERIPHERALLY PLACED CYSTS SEEN IN BOTH KIDNEYS.

10  MRI SHOWING FEW ACUTE HEMORRHAGIC CYSTS IN BOTH KIDNEYS APPEARING HYPOINTENSE ON T1 AND T2.

11  MRI T2 HASTE AXIAL & CORONAL IMAGE SHOWING RIGHT PELVI-URETERIC JUNCTION OBSTRUCTION.

12 .  MRI T2 HASTE SAGGITAL IMAGE SHOWING RIGHT PELVI-URETERIC JUNCTION OBSTRUCTION.

13 .  MRI T2 HASTE CORONAL IMAGE SHOWING LEFT CONGENITAL MEGAURETETR.

14  MRI T2 HASTE SAGGITAL IMAGE SHOWING LEFT CONGENITAL MEGAURETETR.

15  INTRAVENOUS UROGRAPHY & PLAIN CT SHOWING DUPLEX COLLECTING SYSTEM ON RIGHT SIDE.

16  INTRAVENOUS UROGRAPHY SHOWING RIGHT HYDROURETERO NEPHROSIS WITH RETROCAVAL URETER.

17  CONTRAST CT, T2 HASTE SAGITTAL & CORONAL IMAGES SHOWING LEFT DOUBLE MOIETY URETER WITH ECTOPIC URETEROCELE.

18  Congenital abnormalities of the kidneys and urinary tract are common in children.  They are a significant cause of morbidity in infancy.  Many morphological renal changes can be evaluated by imaging studies.  A Right protocol and familiarity with urologic anomalies are essential for correct diagnosis and appropriate management.

19  A. Daneman and D. J. Alton, “Radiographic manifestations of renal anomalies,” Radiologic Clinics of North America, vol. 29, no. 2, pp. 351–363, 1991.  K. Nakanishi and N. Yoshikawa, “Genetic disorders of human congenital anomalies of the kidney and urinary tract (CAKUT),” Pediatrics International, vol. 45, no. 5, pp. 610–616, 2003.  R. Song and I. V. Yosypiv, “Genetics of congenital anomalies of the kidney and urinary tract,” Pediatric Nephrology, vol. 26, no. 3, pp. 353–364, 2011.  S. Hattori, K. Yosioka, M. Honda, and H. Ito, “The 1998 report of Japanese National Registry data on pediatric end-stage renal disease patients,” Pediatric Nephrology, vol. 17, no. 6, pp. 456–461, 2002.  A. Wiesel, A. Queisser-Luft, M. Clementi et al., “Prenatal detection of congenital renal malformations by fetal ultrasonographic examination: an analysis of 709,030 births in 12 European countries,” European Journal of Medical Genetics, vol. 48, no. 2, pp. 131–144, 2005.

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