1. Customizing the Content: The placeholders in this poster are formatted for you. Type in the placeholders to add text, or click an icon to add a table, chart, SmartArt graphic, picture or multimedia file. To add or remove bullet points from text, just click the Bullets button on the Home tab. If you need more placeholders for titles, content or body text, just make a copy of what you need and drag it into place. PowerPoint’s Smart Guides will help you align it with everything else. www.ercforsops.org Customizing the Content: In the section titled “Research Relation to ERC” delete any check- box that does not apply to your research. Customizing the Content: Consider using tables instead of text boxes to organize information and create interesting presentation poster layouts with side-by-side columns of text and graphics. In a table, as on a spreadsheet, you work with rows and columns of cells. You can add and remove rows, merge and split table cells, change row height and column width, align the contents of table cells, apply pre-defined table styles NSF Engineering Research Center for Structured Organic Particulate Systems (C-SOPS) Determination of drug concentration in pharmaceutical powder mixture by near infrared transmission spectroscopy. Presenter(s): Adriluz Sanchez, University of Puerto Rico at Mayaguez Research Participants: Camila Alonso, Mirna Martinez,Andres Roman, Kim H S and Rodolfo Romanach GOALS AND DELIVERABLES 1.Goal: Develop analytical methods capable of discerning between measurement errors and process variation. Deliverables: Development the first work by NIR transmission in pharmaceutical powder mixture A NIR transmission method for drug concentration in powder blends. Previous work has been with tablets. Comparison of transmission and diffuse reflectance measurements to evaluate powder blends. DESCRIPTION MATERIAL AND METHOD DEVELOPMENT RESULTS RESEARCH RELATION TO ERC Conclusions Future Work 1.Discuss development of future system capable of in-line transmission measurements. Table 1. Calibration samples for transmission and diffuse reflectance calibration model s. Figure 1. Bruker Optics Multi-Purpose Analyzer (MPA), Fourier Transform Near Infrared Spectrometer Figure 2. Method development for transmission in powder Figure 5. Transmission spectra of pharmaceutical powder mixture 1. NIR transmission in powder A calibration model using NIR diffuse reflectance in powder were developed with blend of APAP, MCC and lactose.(Table 1). Four calibrations set with different mixing conditions were evaluated.(Table 2). Figure 4. Method development for diffuse reflectance Figure 3. Method development for transmission in powder using a feeder Test set 2t using a feeder (Dynamic sampling ) 1.A test set blend (400 g) of 15% APAP to challenge the calibration model was prepared. 2.Sixty aliquots were obtained from powder feeder using a tablet holder with a glass cell in the background. Table 2. Validation set for transmission model Table 3. Validation set for Diffuse reflectance model Table 4. Comparison between transmission and diffuse reflectance measurement DR spectra were acquired with a Bruker Optics (Billerica, MA) Matrix FT-NIR spectrometer. All spectra were obtained as the powder moved at a linear velocity of 10 mm/s in a conveyor belt. Parameters: resolution 8 cm -1, sample scan 32. 2. NIR diffuse reflectance in powder Method development Calibration sample and Test set 1t preparation using static sampling A tablet holder with a glass cell in the background was used for the transmission measurements of powder. From 0.3044 - 0.3050 g of the blend was placed in the tablet holder. Ten aliquots of each blends were evaluated.