1. © 2008 Applera Corporation and MDS Inc. MultiQuant ™ Software © 2008 Applera Corporation and MDS Inc.

2. MultiQuant ™ Software © 2008 Applera Corporation and MDS Inc. AB SCIEX Protein Research Solutions for Targeted Quantitative Proteomics Multiple MRM transitions to peptides processed as groups. User-defined report formats Time Intensity Cycle Time Supports RELATIVE and ABSOLUTE quantitation

3. © 2008 Applera Corporation and MDS Inc. MultiQuant ™ Software © 2008 Applera Corporation and MDS Inc. One touch productivity... MultiQuant ™ software incorporates many powerful features to convert the mountain of data into results Proteomics and Metabolomics researchers are increasingly turning to MRM quantitation for more targeted and reproducible results… AB SCIEX Protein Research Solutions for Targeted Quantitative Proteomics

4. © 2008 Applera Corporation and MDS Inc. MultiQuant ™ Software © 2008 Applera Corporation and MDS Inc. Normal Early stage disease Late stage disease ABSOLUTE: MRM peak areas are measured relative to synthetic internal standards to determine actual peptide and metabolite abundance. RELATIVE: MRM peak areas for peptides are compared against a global internal standard, created using mTRAQ ™ reagents. MultiQuant ™ software is a powerful solution that supports both RELATIVE and ABSOLUTE Quantitation workflows. Endogenous Peptide Internal Standard Peptide R=0.9989 Standard Concentration Curve AB SCIEX Protein Research Solutions for Targeted Quantitative Proteomics

5. © 2008 Applera Corporation and MDS Inc. MultiQuant ™ Software © 2008 Applera Corporation and MDS Inc. Information for processing standard concentration curves is at your fingertips. AB SCIEX Protein Research Solutions for Targeted Quantitative Proteomics MultiQuant ™ software has many powerful features to enable quantitative workflows…

6. © 2008 Applera Corporation and MDS Inc. MultiQuant ™ Software © 2008 Applera Corporation and MDS Inc. When mTRAQ ™ reagents are used, area ratios to internal standards for every peptide are automatically computed. Multiple MRM transitions to peptides are automatically processed as groups and peak integrations are easily visualized. AB SCIEX Protein Research Solutions for Targeted Quantitative Proteomics Results can easily be exported to user-defined report formats.

7. © 2008 Applera Corporation and MDS Inc. MultiQuant ™ Software © 2008 Applera Corporation and MDS Inc. AB SCIEX Protein Research Solutions for Targeted Quantitative Proteomics One touch productivity.