1. Publication Cho, E., et al., Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies. Annals of Internal Medicine, 2004; 140: 603-613.

2. Sweden Mammography Cohort Nurses’ Health Study Netherlands Cohort Study New York State Cohort Iowa Women’s Health Study Canadian National Breast Screening Study Cohort Studies in the Pooled Analysis of Alcohol and Colorectal Cancer Alpha-Tocopherol Beta- Carotene Cancer Prevention Study Health Professionals Follow-up Study Cho, et al., 2004 Total = 489,979 # of cases = 4,687

3. Cohort Studies in the Pooled Analysis of Alcohol and Colorectal Cancer Study Total # of cohort cases ATBC 26,987 184 Canadian National Breast 56,837 284 Screening Study Health Professionals 47,673 408 Follow-up Study Iowa Women’s Health Study 34,603 796 Netherlands Cohort Study 120,852 1126 New York State Cohort 52,913 789 Nurses’ Health Study (a) 88,651 220 Nurses’ Health Study (b) 68,540 420 Sweden Mammography Cohort 61,463 460 Cho, et al., 2004

4. Total Alcohol Intake Study % Drinkers Mean* (SD) (g/d) ATBC 8920.3 (21.8) Canadian National 7710.9 (14.5) Health Professionals 7614.8 (16.1) Iowa Women’s 458.7 (12.3) Netherlands Study (W)688.5 (10.6) Netherlands Study (M) 8517.3 (16.7) New York State Cohort (W) 786.0 (9.4) New York State Cohort (M) 8912.1 (17.1) Nurses’ Health Study (a)689.4 (11.6) Nurses’ Health Study (b)649.6 (12.1) Sweden Mammography Cohort673.5 (3.5) *Among drinkers only Cho, et al., 2004

5. Alcohol and Colorectal Cancer Intake No. of Multivariate RR (g/d)cases(95% CI) 01,466 1.00 (ref) >0-<51,475 0.94 (0.86-1.03) 5-<15 849 0.97 (0.88-1.06) 15-<30 485 1.01 (0.86-1.18) 30-<45 244 1.16 (0.99-1.36) >45 168 1.41 (1.16-1.72) P for trend <0.001 Cho, et al., 2004

6. Study-Specific Relative Risks for Colorectal Cancer for Alcohol Intake > 30 vs. 0g/d Cho, et al., 2004

7. Alcohol Intake and Colorectal Cancer by Tumor Site RR (95% CI) Intake (g/d) Colon Rectum 01.001.00 >0 - <50.921.01 5 - <150.940.99 15 - <301.011.05 30 - <451.081.42 >451.451.49 (1.14-1.83) (1.04- 2.12) P for trend <0.001 0.006 Cho, et al., 2004

8. Alcoholic Beverages and Colorectal Cancer Intake BeerWineLiquor (g/d) 01.001.00 1.00 >0-<301.010.97 0.98 >301.371.82 1.21 (1.00-1.87) (1.28-2.59) (0.99-1.47) P for trend0.2 0.001 0.1 Cho, et al., 2004

9. Alcoholic Beverages and Colorectal Cancer by Tumor Site Alcoholic Tumor RR (95% CI) beverage site(>15 vs. 0 g/d) Beer Colon1.38 (1.05-1.82) Rectum1.59 (1.12-2.25) Wine Colon1.33 (1.00-1.77) Rectum1.55 (1.11-2.17) Liquor Colon1.06 (0.86-1.30) Rectum1.10 (0.85-1.41) For each beverage, the differences by tumor site were not statistically significant. Cho, et al., 2004

10. Alcohol and Colorectal Cancer by Body Mass Index P for interaction=0.03 * *P<0.05 Relative Risk 0 >0- 30 Cho, et al., 2004 BMI <2222-<2525+ kg/m 2 Alcohol (g/d)

11. Alcohol and Colorectal Cancer by Multivitamin Use P for interaction >0.2 * *P<0.05 Relative Risk Alcohol (g/d) 0 >0- 30 Cho, et al., 2004 Nonusers Users