1. THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1947

2. The Nobel Prize in Physics 1947 "for his investigations of the physics of the upper atmosphere especially for the discovery of the so-called Appleton layer" Sir Edward Victor Appleton (United Kingdom)

3. The Nobel Prize in Chemistry 1947 "for his investigations on plant products of biological importance, especially the alkaloids" Sir Robert Robinson (United Kingdom)

4. The Nobel Prize in Literature 1947 "for his comprehensive and artistically significant writings, in which human problems and conditions have been presented with a fearless love of truth and keen psychological insight" André Paul Guillaume Gide (France)

5. The Nobel Peace Prize 1947 Friends Service Council (The Quakers) London, United Kingdom American Friends Service Committee (The Quakers) Washington, DC, USA

6. "for their discovery of the course of the catalytic conversion of glycogen" GERTY THERESA CORI, NÉE RADNITZ USA (1896-1957) 3 rd woman to win the Noble prize. CARL FERDINAND CORI USA (1896-1984) THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1947

7. The Cori cycle is their explanation for the movement of energy in the body— from muscle, to the liver, and back to muscle.Cori cyclemusclelivermuscle CORI CYCLE

8. Bernardo Alberto Houssay (Argentina) "for his discovery of the part played by the hormone of the anterior pituitary lobe in the metabolism of sugar" (April 10, 1887 – September 21,1971)

9. Carbohydrates produced from food or liver Used by muscles Production and consumption of carbohydrates-Constant blood sugar level The liver Hypoglycemia when liver is removed Hyperglycemia-the liver diminishes or ceases the production of sugar, and stores it.

10. The pancreas secretes insulin in adequate quantities so as to maintain a normal blood sugar level, and the blood sugar level regulates the amount of insulin secreted. Thus hyperglycemia increases the secretion of insulin and hypoglycemia diminishes or completely inhibits it.

11. He found that hypophysectomized dogs were hypersensitive to the toxic and hypoglycemic action of insulin These discoveries stimulated the study of harmonal feedback control mechanisms which are central to all aspects of modern endocrinology. endocrinology

12. Outline Carbohydrate metabolism and other metabolic processes are regulated by the balance maintained between the secretion of several endocrine glands. Diabetes and other metabolic diseases are a disturbance in this endocrine equilibrium.

13. FIGURE SHOWING THE ANTERIOR PITUTARY LOBE

14. Due to the body's ability to hold no more than around 2,000 kcal of glycogen, marathon runners commonly experience a phenomenon referred to as "hitting the wall" around the 20 mile (32 km) point of a marathon. (Approximately 100 kcal are utilized per mile, depending on the size of the runner and the race course.) When experiencing glycogen debt, runners many times experience fatigue.

15. References http://nobelprize.org/ http://en.wikipedia.org/wiki/Main_Page