1. Carbon Based Life Life is based upon 20 different chemical elements Four of these make up 96% of the mass in cells Oxygen …… 65.0% Carbon …... 18.5% Hydrogen …. 9.5% Nitrogen …… 3.3% Why not Oxygen based life??? Most Oxygen is bound in water molecules! Carbon has the diversity and strength of chemical bonds (4 bonds at a time!) Oxygen can do 2 bonds at a time Hydrogen can do 1 bond at a time

2. Molecular Structures Though we will mostly view the “Structural formula” models, note the three- dimensional configuration of the more telling “Ball-and-stick” model. The “H” atoms are as far apart from one another as possible due to the repulsion of the positively charged nuclei. The “Space filling” model shows the “electron clouds”.

3. Molecular Structures Functional Groups in Biology and Metabolism

4. Carbon is versatile… Forming anywhere from 1 to 4 bonds at a time! These are called hydrocarbons… carbon skeletons bonded with hydrogen atoms Complex organic molecules are hydrocarbons with other elements bonded in them Organic Molecules = double bonds - single bonds Silicon (also abundant in the universe) is very similar to carbon, but cannot form double bonds and its single bonds are significantly weaker than carbon bonds

5. Handedness In nature (and in space), molecules come in both “left” and “right” handed chirality… ALL life on earth utilizes only “left” handed. Since molecules operate on a “lock and key” basis, it would be expected that this phenomenon would be present in life elsewhere.

6. Components of Cells 4 main classes of complex organic molecules in cells… 1.Carbohydrates - provide energy, build sturdy structures (cellulose, fiber, cell integrity) 2.Lipids - fats, store energy for future use, form cell membranes (protective barriers) 3.Proteins - work horse of cells, long carbon chains built from amino acids 4.Nucleic Acids - DNA (genetic), RNA (messenger and transfer molecules) Here again, is the organization and specialization phenomenon for life’s self sustenance.

7. Two Basic Cell Types Prokaryotic Cell Eukaryotic Cell All living cells based upon same molecules and common chemistry… but two types… most common simple, single celled only smaller have NO nucleus Prokaryotes: Bacteria and Archaea E-coli & Salmonella complex, single or multicellular larger have nucleus Eukarea single celled include Amoeba Genetic material not as protected Genetic material “double” protected Eukaryotes need Prokaryotes to survive!

8. Here again, is the organization and specialization phenomenon for life’s self sustenance. Two Basic Cell Types

9. Three Domains of Life (by cell type) Prokaryotic Cells Eukaryotic Cells We no longer use the classification of “kingdoms”, such as plant kingdom or animal kingdom… Genetic similarities and therefore heritage suggest three basic domains, where Archaea and Bacteria split and then all Eukarya split from Archaea Bacteria and Archaea are both Prokarya… All animals and plants are Eukarya… Genetically, Archaea and Eukarya are more similar to one another than are Bacteria and Archaea This has implication for the evolution of life on Earth… One reason we believe that all organisms had a common ancestor.

10. Metabolic Classes Photo = sunlight Auto = carbon dioxide only Chemo = chemicals Hetero = organic compounds

11. Metabolism is Chemoheterotrophs ATP Power The phosphate group bonding and bonding breaking of the phosphate group from the ADP molecule is the energy source in the cell ADP = adenosine diphosphate ADP = adenosine triphosphate

12. Energy released when ATP splits into ADP and a Phosphate

13. Deoxyribonucleic Acid Discovered less than 50 years ago Spiral stranded “double helix” structure is very robust, like a skeleton. The connecting “teeth” within the stands are called the DNA bases, and these bases hold the keys to heredity through DNA replication. A = adenine G = gaunine T = thymine C = cytosine T links to A only C links to G only Four bases in different combinations manifest all forms of life within and across species and plants!

16. DNA Packaging Chromosomes

17. DNA Replication