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BIPN 148 Lecture 9
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How are synaptic changes regulated? Malenka and Nicoll, 1995
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Biochemical Basis of LTP
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Modulation of NMDA receptors
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Calcium signaling and LTP/LTD
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Calcium activation of CaM kinases
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TTT CatalyticAutoinhibitorySelf-association Inhibitory Calmodulin Binding 286 Autonomous Activity 305/306 Inhibitory A BC PP Structure of CaMKII Verdaguer et al. (1999) Embo. J. 18:6329-6338.
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Calcium activation of CaMKII
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Persistent activation of CaMKII
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NMDA Receptor CaMKII Transient CaMKII Activation Thr 286 Autophosphorylation (persistently active) NMDAR Association (persistently active) CaMKII Ca ++ / CaM Effects of Ca/CaM on CaMKII
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CaM Kinase II and potentiation Wang and Kelly 1995
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LTP in Thr286A mutant mice
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Lissman, 1991 How might CaMKII affect synaptic function?
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NR2B interaction with CaMKII
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LTP-induced changes in AMPA currents
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LTP phosphorylation of AMPA-R
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