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BIPN 148 Lecture 10. Biochemical Basis of LTP Modulation of NMDA receptors.

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Presentation on theme: "BIPN 148 Lecture 10. Biochemical Basis of LTP Modulation of NMDA receptors."— Presentation transcript:

1 BIPN 148 Lecture 10

2 Biochemical Basis of LTP

3 Modulation of NMDA receptors

4 Calcium signaling and LTP/LTD

5 Calcium activation of CaM kinases

6 TTT CatalyticAutoinhibitorySelf-association Inhibitory Calmodulin Binding 286 Autonomous Activity 305/306 Inhibitory A BC PP Structure of CaMKII Verdaguer et al. (1999) Embo. J. 18:6329-6338.

7 Calcium activation of CaMKII

8

9 Persistent activation of CaMKII

10 Temporal Integration of a Ca Signal by CaMKII Dineley et al. (2001) J. Neurochem. 77:961-971.

11 NMDA Receptor CaMKII Transient CaMKII Activation Thr 286 Autophosphorylation (persistently active) NMDAR Association (persistently active) CaMKII Ca ++ / CaM Effects of Ca/CaM on CaMKII

12 LTP in Thr286A mutant mice

13

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