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Neu 200 Molecular Mechanisms of Plasticity. Biochemical Basis of LTP.

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Presentation on theme: "Neu 200 Molecular Mechanisms of Plasticity. Biochemical Basis of LTP."— Presentation transcript:

1 Neu 200 Molecular Mechanisms of Plasticity

2 Biochemical Basis of LTP

3 Calcium activation of CaM kinases

4 Calcium activation of CaMKII

5 LTP is reduced in Thr286A mutant mice

6 LTP-induced changes in AMPA currents

7 Glycine induces potentiation

8 Glycine increases surface GluR1

9 Phosphorylation of GluR1 by LTP

10 GluR1 phosphorylation at S831

11 S831 phosphorylation of GluR1is required for glycine-induced potentiation

12 Model of AMPA-R regulation

13 Evidence for GluR1 insertion at synapses

14 CaMKII effect on synaptic responses

15 Effect of S831A, S845A on LTP

16 Generation of S831/845- mice

17 Plasticity in S831/845- mice

18 Role of GluR1 trafficking in fear conditioning: Physiology of GluR1 transfected neurons in Amygdala

19 Expression of GluR1-C inhibits plasticity in Amygdala

20 Expression of GluR1-C inhibits fear conditioning

21 Biochemical Basis of LTP

22 Spatial learning induces gene expression

23 Calcium regulation of gene expression

24 CaM Kinase IV activates CREB

25 CaM Kinase IV phosphorylates CREB

26 LTP in dnCKIV mice

27 dnCaMKIV suppresses fear conditioning

28 Spatial learning in dnCKIV mice

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