1. Case (1)S A young patient was complaining of a single hard painless ulcer around his mouth. After examination doctor noticed that all his vital signs were normal, but he decided to take serous fluids from this ulcer for microscopical examination and blood sample for serological tests.

2. Case (1)S A single hard painless ulcer around his mouth.

3. Case (1)S Serous fluids from this ulcer was stained by fontana showing spiral organism

4. Case (1)S Questions : 1. What is your provisional diagnosis? 2.Name the stage in this patient, and justify? 3.What is the most likely causative organism of this disease ? 4.Describe the confirmatory tests of this disease?

5. Case (1)S If the previous patient developed skin rashes, loss of hair, fever and malaise. 5- Which stage of the disease is this? 6-When does this stage occur ?

6. Case (1)S If the previous patient had large degenerative lesions on his skin. 7- What is the possible stage of the disease and what are the lesions called ?