1. AP Biology 2004-2005 Teaching Biology Through Bioinformatics Real world genomics research in your classroom Kim B. Foglia Division Ave. High School Levittown Stuart M. Brown, PhD Director of Research Computing NYU School of Medicine

2. Bioinformatics 2005-2006 Bioinformatics  Use of computers to analyze genomic data for molecular biology research  basic biological research  medical research  clinical medicine application  taxonomy

3. Bioinformatics 2005-2006 Bioinformatics is a great way to learn biology  Using computers to study primary biological data (genomes, proteins, other databases)  students learn biology as a dynamic process of interpreting complex data  students can reproduce current scientific work & ask new questions  science is no longer just a collection of facts in a textbook, it’s a process of inquiry

4. Bioinformatics 2005-2006 Teaching Biology with Bioinformatics  Bioinformatics tools lead directly to insights about genes, proteins, evolution  “Hey! Most human genes have more bases of introns than they do exons.”  “Hemoglobin sequences show that seals are closer to weasels than they are to whales.”  “Protein shapes determine their function, so small changes can make a big difference.”

5. Bioinformatics 2005-2006 All you need…  Students can work on bioinformatics questions at low cost  only need Internet connected computers  most database tools are free on Internet  unlimited data  GenBank, protein structures, mutations, microarrays, etc.  teacher knowledge & “comfort”  questions to answer

6. Bioinformatics 2005-2006 What we offer…  Teaching modules  inquiry labs  student & teacher lab handouts  supporting teaching resources  PowerPoint presentations  Supplemental skills modules  Download from Web site  http://bio.kimunity.com

7. Bioinformatics 2005-2006 Modules in development  Testing for Sickle Cell Anemia  develop a genetic diagnostic test to screen for disease  Endosymbiosis  evolutionary history mitochondria & chloroplasts  Hemophilia Gene Therapy  build a vector and insert correct gene  Are Seals and Whales Related?  studying evolutionary relationships