1. Biochemical Evolution Ibarra Jonatanh Ouředničková Veronika Faculty of chemistry, Brno University of Technology

2. Vocabulary ENCZENCZ AcquireZískatEnablingUmožnující Pass onPředatResponseOdezva TraitsVlastnostiRequiringPožadující DiversityRozmanitostAllowDovolit VastObrovskýRemarkablyPozoruhodně RatePoměrAncestorPředek IncreasinglyZvýšeněPathsCesty

3. Biological Evolution  The process by which populations of organisms acquire and pass on novel traits from generation to generation. Its action over large stretches of time explains the origin of new species and ultimately the vast diversity of the biological world.

4. Biochemical Evolution  Chemosynthesis: hypothesis to explain how life might possibly have developed from non- life.  Three stages:

5. 1 st Stage of Evolution  The initial generation of some of key molecules of life (nucleic acids, proteins, carbohydrates, lipids) by non-biological processes.  The prebiotic world.  Urey-Miller experiment

6. 1 st Stage of Evolution  The Earth´s early atmosphere was probably highly reduced, rich in CH 4, NH 3, H 2 O, H 2 + large amounts of solar radiation and lightning. Urey-Miller experiment (1950).  Prebiotic „lake“ – cold (under 0°C; clays); polymer synthesis rate must be higher than their hydrolysis (slow at low temperature).

7. 2 nd Stage of Evolution  The transition from prebiotic chemistry to replicating systems; with the passage of time, these systems became increasingly sophisticated, enabling the formation of living cells; membrane formation.  Formation of replicating molecules, variation and selective pressure = beginning of evolution.

8. 2 nd Stage of Evolution  RNA – an early replicating molecule; some RNA molecules possess catalytic activity, this was transferred to proteins  RNA directed the synthesis of proteins and still does in modern organisms through the development of a genetic code.  RNA lost its role as the gene to the chemically similar but more stable DNA  Evolution of membranes (hydrophobic barriers) – first unicellular organisms.

9. 3 rd Stage of Evolution  The biological evolution; energy-conversion processes (photosynthesis) and pathways for synthesizing the components of biopolymers from simpler molecules; evolution of unicellular organisms; colonies; differentiation and formation of multicellular organisms; response to environmental changes

10. 3 rd Stage of Evolution  The final transition was the evolution of sensing and signaling mechanisms that enabled a cell to respond to changes in its environment; cell-cell communication allowed the development of more-complex organisms.

11. Evolutionary tree – “the tree of life”  Organisms are remarkably uniform at the molecular level.  Uniformity life have come into existence only once (Darwin).

12. Evolutionary tree – “the tree of life”  This uniformity reveals that all organisms on Earth have arisen from a common ancestor (bacteria are no direct ancestors of higher organisms)  Evolutionary paths from a common ancestor to modern organisms can be developed and analyzed on the basis of biochemical information

13. Thank you for your attention