1. 1 CGN Research Labs Pvt. Ltd. BSI - ISO 9001:2008 & 13485:2003 1609, NorthRidge Ct Appleton, Wisconsin, USA. Phone: 001 920 277 8856. www.cgnresearchlabs.com # 8-155/1, Janani Towers, M.R. Palli Circle, AIR Bypass Road, Tirupati – 517502, Phone: 0877 – 2245500.

2. 2 Awards:  CGN Research Labs is a BSI – ISO 9001:2008 & ISO 13485:2003 Certified Company.  2009 - Philips Best Innovation Award.  2010 - DST Lockheed Martin Gold Medal Winner.  2011 - Best Medical Electronics Product of the Year.  2011 - Winner of GBI Gold Medal.  2012 - CRISIL MEDICALL Healthcare innovation Award (Gold Medal). Category – IT & Medical equipment.

3. Certifications / Affiliations 3 2012 - CGN Research Labs is a CE ( Conformity European ) Certified company 2013 - CGN Research Labs is a Member in ESC (Electronics and computer software export promotion council) 2013 - CGN Research Labs is a MEMBER in FAPPCI. 2013 - CGN Research Labs is approved by MOH, United Arab Emirates (UAE). 2013 - Free sale and commerce certificate issued by Ministry of commerce, INDIA.

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6. 6 A Device for detection of Inflammatory Pain, Vascular Disorders and Breast Cancer. THERMOSCAN

7. Introduction Thermoscan is a noninvasive, painless and no harmful imaging technology that allows the physician to visualize the physiological dynamics at an early stage. Thermoscan converts infrared radiation emitted from the skin surface into electrical impulses that are visualized in colour on a monitor. This visual image graphically maps the body temperature and is referred to as a thermogram. The spectrum of colours indicate an increase or decrease in the amount of infrared radiation being emitted from the body surface Thermoscan clinical value is in its high sensitivity to pick up pathological changes due to diseases of muscular, skeletal, vascular systems at just aberrant physiological level itself. 7

8. 8 Potential Application areas Rheumatology Neurology Oncology Diabetes ( Endocrinology) Radiology Orthopedics Sports medicine Physiotherapy Pain Management Wound Healing

9. Clinical Implications Diabetic foot care Assessing stage of wound healing Diagnosing and Imaging pain ( Distinguishing Inflammatory and Neuropathic pain) Screening of the Breast Cancer Assessing the response of disease to treatments 9

10. Diabetic foot care Diabetic foot problem is the most common reason for patient admissions to hospital worldwide. Diabetic foot care is the most vital factor for control of blood glucose. 10

11. Possible patterns of Planter and Calcaneal Vascular anatomy: A concept of “Angiosome” 11

12. ** MPA: Medial Plantar Artery LPA: Lateral Plantar Artery MCA: Medial Calcaneal Artery LCA: Lateral Calcaneal Artery 12 Conceptual classification of the thermographic Patterns with 20 different categories

13. 13 DIABETIC MELLITUS GROUP Diabetic Foot

14. 14 An example of latent inflammation identified by Thermography *(A) Photograph - An arrow indicates the callus. *(B) Thermography - An arrow indicates elevated temperature.

15. Stage 1: Inflammatory Phase Stage 2: Proliferative Phase Stage 3: Epithelisation Phase Stage 4: Remodeling Diabetic foot Assessing stage of wound healing 15

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17. 17 Wound Management Assisted Healing HBOT NSP Radiation Involved Anodyne LLLT Wound Dressing Skin Grafts ECM RPDGF

18. 18 PAIN MSK Skeletal Pain Inflammatory 1. Rheumatoid arthritis 2. Psoriatic Arthritis 3. Inflammatory Spondylitis Non Inflammatory Osteoarthritis Hemochromatosis Acromegalic Arthopathy Muscular Pain Levator scapula Neurological

19. 19 Rheumatoid Arthritis (Symmetrical, Small & Large Joints Upper and lower limbs) Psoriatic Arthritis (Asymmetrical, Large >Small joints, Dactyl ties) Inflammatory Spondylitis Asymmetrical Axial involvement, Larger > Small joints

20. 20 Knee Abdomen Rheumatoid Arthritis Osteoarthritis Complex Regional Pain Syndrome(CRPS) Inflammatory pain thermal images

21. THERMOGRAM 21 Screening for Breast Cancer. 21

22. 22 PATIENT REPORT – HIGH RISK THERMOGRAM breast cancer was diagnosed after further evaluation

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24. Thermal image of Back before LLLT Thermal image of Back after LLLT Assessing the response of disease to treatment like LLLT treatment. 24

25. Thermal image of Neck before LLLT Thermal image of Neck after LLLT 25

26. 26 CGN Research Labs Pvt. Ltd. BSI - ISO 9001:2008 & 13485:2003