1. Microbiology: A Systems Approach, 2 nd ed. Chapter 21: Infectious Diseases Affecting the Respiratory System

2. 21.1 The Respiratory Tract and Its Defenses Most common place for infectious agents to gain access to the body Upper respiratory tract: mouth, nose, nasal cavity, sinuses, pharynx, epiglottis, larynx Lower respiratory tract: trachea, bronchi, bronchioles, lungs, alveoli Defneses – Nasal hair – Cilia – Mucus – Involuntary responses such as coughing, sneezing, and swallowing – Macrophages – Secretory IgA against specific pathogens

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4. 21.2 Normal Biota of the Respiratory Tract Generally limited to the upper respiratory tract Gram-positive bacteria (streptococci and staphylococci) very common Disease-causing bact4eria are present as normal biota; can cause disease if their host becomes immunocompromised or if they are transferred to other hosts (Streptococcus pyogenes, Haemophilus influenza, Streptococcus pneumonia, Neisseria meningitides, Staphylococcus aureus) Normal biota perform microbial antagonism

6. 21.3 Upper Respiratory Tract Diseases Caused by Microorganisms Rhinitis, or the Common Cold – Symptoms: sneezing, scratchy throat, runny nose (rhinorrhea) – Symptoms begin 2-3 days after infection – Generally not accompanied by fever

8. Sinusitis – Commonly called a sinus infection – Most commonly caused by allergy – Can also be caused by infections or structural problems – Generally follows a bout with the common cold – Symptoms: nasal congestion, pressure above the nose or in the forehead, feeling of headache or toothache – Facial swelling and tenderness common – Discharge appears opaque with a green or yellow color in case of bacterial infection – Discharge caused by allergy is clear and may be accompanied by itchy, watery eyes

10. Acute Otitis Media (Ear Infection) Also a common sequel of rhinitis Viral infections of the upper respiratory tract lead to inflammation of the Eustachian tubes and buildup of fluid in the middle ear- can lead to bacterial multiplication in the fluids Bacteria can migrate along the eustachian tube from the upper respiratory tract, multiply rapidly, leads to pu production and continued fluid secretion (effusion) Chronic otitis media: when fluid remains in the middle ear for indefinite periods of time (may be caused by biofilm bacteria) Symptoms: sensation of fullness or pain in the ear, loss of hearing Untreated or severe infections can lead to eardrum rupture

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13. Pharyngitis Inflammation of the throat Pain and swelling, reddened mucosa, swollen tonsils, sometime white packets of inflammatory products Mucous membranes may swell, affecting speech and swallowing Often results in foul-smelling breath Incubation period: 2-5 days

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19. Diphtheria Symptoms initially experienced in the upper respiratory tract Sore throat, lack of appetite, low-grade fever Pseudomembrane forms on the tonsils or pharynx

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24. 21.4 Diseases Caused by Microorganisms Affecting the Upper and Lower Respiratory Tract A number of infectious agents affect both the upper and lower respiratory tract regions Most well-known: whopping cough, respiratory syncytial virus (RSV), and influenza

25. Whooping Cough Also known as pertussis Two distinct symptom phases – Catarrhal stage After incubation from 3 to 21 days Bacteria in the respiratory tract cause what appear to be cold symptoms (runny nose) Lasts 1 to 2 weeks – Paroxysmal stage Severe and uncontrollable coughing Violent coughing spasms can result in burst blood vessels in the eyes or even vomiting Followed by a long recovery (convalescent) phase – Complete recovery requires weeks or even months – Other microorganisms can more easily cause secondary infection

27. Respiratory Syncytial Virus Infection Produces giant multinucleated cells (synctia) in the respiratory tract Most prevalent cause of respiratory infection in the newborn age group First symptoms: fever that lasts approximately 3 days, rhinitis, pharyngitis, and otitis More serious infections give rise to symptoms of croup: coughing, wheezing, dyspnea, rales

29. Influenza Begins in the upper respiratory tract; serious cases may also affect the lower respiratory tract 1- to 4-day incubation period Symptoms begin very quickly: headache, chills, dry cough, body aches, fever, stuffy nose, and sore throat Extreme fatigue can last a few days or a few weeks

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33. 21.5 Lower Respiratory Tract Diseases Caused by Microorganisms Diseases that affect the bronchi, bronchioles, and lungs Tuberculosis and pneumonia

34. Tuberculosis Humans are easily infected with Mycobacterium tuberculosis but are resistant to the disease Only about 5% of infected people actually develop a clinical case of TB Untreated TB progresses slowly Clinical TB is divided into primary tuberculosis, secondary tuberculosis, and disseminated tuberculosis

35. Primary Tuberculosis Period of hidden infection- asymptomatic or accompanied by mild fever After 3 to 4 weeks, immune system mounts a cell-mediated assault- large influx of mononuclear cells into lungs Tubercles form Frequently the centers of tubercles break down into necrotic caseous lesions that gradually heal by calcification Tuberculin reaction

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38. Secondary (Reactivation) Tuberculosis Live bacteria can remain dormant and become reactivated weeks, months, or years later Chronic tuberculosis: tubercles filled with bacteria expand and drain into bronchial tubes and upper respiratory tract; severe symptoms such as violent coughing, greenish or bloody sputum, low-grade fever, anorexia, weight loss, extreme fatigue, night sweats, chest pain

39. Extrapulmonary Tuberculosis Outside of the lungs More common in immunosuppressed patients and young children Regional lymph nodes, kidneys, long bones, genital tract, brain, and meninges Complications are usually grave

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44. Pneumonia Anatomical diagnosis Inflammatory condition of the lung in which fluid fills the alveoli Can be caused by a wide variety of different microorganisms Viral pneumonias are usually milder than bacterial Community-acquired vs. nosocomial pneumonias Begin with upper respiratory tract symptoms, including runny nose and congestion Headache common Fever is often present Onset of lung symptoms follows: chest pain, fever, cough, discolored sputum

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