1. Thermo Scientific Konelab PRIME 60 and Konelab PRIME 30

2. Fully automated clinical chemistry systems
For medium sized laboratories as a stand-alone instrument
For high volume testing as a part of automated workcell
Konelab PRIME 60: Capacity up to 600 tests/hour depending on workload
Konelab PRIME 30: Capacity up to 300 tests/hour depending on workload

3. WORKCELL Automation Single entry point without pre-sorting
Minimizes the need of aliquots
Workload balancing
Centralized control over the system

4. Continuously expanding test range
Over 80 carefully validated methods for
Enzymes
Substrates
Electrolytes
Specific proteins
Drugs of Abuse Tests
Therapeutic Drug Monitoring
CE marked applications can be complemented with user-definable tests

5. Product overview Continuous access to samples, reagents and cuvettes
On-board capacity of
84 routine samples, 6 STAT samples
39 fixed calibrator & control samples
45 reagents in the refrigerated disk
600 cuvette storage positions in PRIME 30, 2100 in PRIME 60
ISE option: K+, Na+, Cl-,
also Li+ and Ca2+ as optional extra
Interface to a sample track system

6. Operational efficiency
Automated sample pretreatment feature
Automatic sample clot detection
Versatile dilution features
Pre-dilution possibility
Post-dilution with both high and low secondary dilution ratios
Calibrator set made automatically from one stock calibrator for most specific proteins
Different sample types can be analysed at the same time
Important in drug monitoring and therapeutic control
Reflex testing
Saves time and money when finding out the specific test to be run
E.g. A patient is having a severe chest pain and you don’t know if s/he is having acute myocardial infarction or not. There is no point of running lots of expensive tests if the basic test is negative. Reflex testing in Konelab can be programmed so that if the creatine basic test is within a normal range then no more tests have to be run, but if it is elevated then the system runs a more specific test.

7. Productive, accurate analysis
User-safe and contamination free measurement
Proven, unique, single use 12-cell cuvette
Cost-effective due to low reaction volume
Only 100 to 250 l
Typically l
Flexibility and long walk-away time
Cuvette storage enables up to 4 hours walk-away time
Continuous loading access without interrupting testing

8. Advanced design to facilitate routine work
Integrated workstation with touch screen
Enables a working posture with less physical strain
Ideal for limited space
Intuitive graphical user-interface
Provides fast guidance
Makes the analyser easy to use
Available in more than 15 language versions

9. Safe sample handling Error free sample handling Sample tubes
Automatic sample identification, direct barcode reading and cup/ tube recognition
Bidirectional LIS interface for quick data transfer
Sample tubes
5, 7 and 10 ml tubes
0.5 and 2 ml sample cups
Calibrators and controls
Cooled positions
Possibility to load also into segments

10. Automated sample pretreatment
Saves the operator time, e.g. by automating hemolyzation in HbA1c measurement
Improves quality by minimizing operator variation
Dedicated sample segment for whole blood samples
For one segment hemolyzation takes about 10 min, total turnaround time about 30 min

11. KUSTI - optional module for point-in-space dispensing
Making automatically an aliquot from the primary sample
Equipped with a 92-positions segment
While part of automated workcell requested tests processed autonomously
Sample is sent further to the next analyzer
Minimizing delays on the sample conveyor
Manual sample loading using segments possible at the same time

12. Automatic clot detection
To secure result integrity
Based on pressure differential technology
Both in sample and KUSTI dispensers
The pressure system is calibrated
By making a series of air aspirations, takes appr. 5 seconds, no extra solutions needed
At start up with sample dispenser
At every water wash with KUSTI
Operator is alarmed about clot
All requests are cancelled for that sample
Extra wash is performed for needles

13. Clot detection in sample dispenser
Pressure signals of succesful aspirations on sample dispenser
The pressure dives in an aspiration and returns through a maximum to the rest level 20 40 60 80
100
120
140
160
180
200 1 21 41 61 81
101
121
141
161
181
201 OK
Clot
The clot message is sent if in aspiration maximum fails to reach the rest level or if the end pressure of the curve remains too far below the rest level

14. Clot detection in KUSTI dispenser
Pressure signals of a succesful aspiration
In each sub-aspiration the pressure signal dives to a certain depth, but returns to the rest level between aspirations
The clot message is sent if in aspiration the pressure dives deeper than in a successful aspiration

15. Convenient reagent handling
Continuous monitoring possibility
Flagging of expired reagents
Determination of vial volume
Estimation of reagent sufficiency
Automatic bottle change-over increases the walk-away time
Possibility to run QC with every new bottle
Used reagent lots can be archived

16. Simultaneous electrolyte measurement
Direct measurement method used in Konelab
Generally considered the most accurate ISE method
Serum, plasma and urine samples
Direct or by manually pre-diluted urine sample
Micro volume electrodes for even smaller sample volumes
Sample volume of only 50 l is sufficient for Na+, K+ and Cl-
Additionally 6 l if Li+, Ca 2+ or pH is required
Maintenance-free electrodes
Delivered ready-to-use

17. Proactive support Minimal user maintenance tasks Maintenance contracts
About 5 min daily
Start up and Stand by procedures
Maintenance contracts
6 and 12 months programs

18. Proven technology and experience
Konelab analyzers are supported with
Customized installation
Product training
Product & Application support
After-sales support
Maintenance contracts
Technical service

19. Confirmed quality
Quality system is certified according to the ISO 9001:2000 standard extended with the EN ISO 13485:2003
Konelab Analyzer systems comply with the requirements of the In Vitro Diagnostic Medical Device Directive (IVDMDD)

20. Key benefits of Konelab analyzers
Easy to use
Clearly laid out, simple to navigate user interface
Automation and analyst efficiency
Once loaded, the analyzer will run without the assistance of the analyst
Automatic dilution of an over range sample
Automated sample pretreatment feature
Reflex test possibility
Clot detection
Different types of samples can be analysed at the same time
Important in drug monitoring and therapeutic control
Productivity
Low reagent volumes -> low cost per test, important in expensive tests
Quick daily start up
Minimal maintenance
User-safe and contamination free analysis
Disposable cuvettes

21. Key benefits of Konelab analyzers
Carefully selected methods and applications
Over 150 CE-marked reagents
Optimized kits serve laboratories of all sizes
Liquid stable and ready for use
System-specific multi-calibrators and controls
Flexible software
Easy method set-up
Special applications to be validated by the customer or distributor
Direct electrolyte measurement
The most accurate ISE method
Maintenance-free electrodes delivered ready-to-use
Full application and technical support

22. One reagent line to be used in all Konelab analyzers
Albumin ACP
Total and Direct Bilirubin ALP
Carbon Dioxide ALT/GPT
Calcium AST/GOT
Cholesterol Amylase
HDL and LDL Cholesterol Cholinesterase
Creatinine Dibucaine
Glucose CK
Iron CK-MB
Magnesium Gamma-GT
Phosphorus -HBDH
Total Protein LDH
Triglycerides Lipase
U/CSF Protein
Urea
Uric Acid Na, K, Cl
Ca, pH
Albumin
Antistreptolysin O
 -1-Antitrypsin
Apolipoprotein A1 and B
Ceruloplasmin
Complement C3 and C4
C-reactive protein
Cystatin C
High Sensitive CRP
HbA1c
Haptoglobin
IgA, G and M
Lipoprotein (a)
Microalbuminuria
Myoglobin
Orosomucoid
Prealbumin
Rheumatoid factors
Transferrin
Amphetamine
Barbiturates
Benzodiazepines
Cannabinoids
Cocaine Metabolite
Opiates
Cotinine
Ethyl Alcohol
Methadone
Propoxyphene
Carbamazepine
Phenobarbital
Phenytoin
Theophylline
Valproic Acid
Lithium
Enzymes
Substrates
DoA (DAT)
Specific Proteins
TDM
Electrolytes

23. Konelab PRIME 60 and PRIME 30
Operational efficiency and
accurate results!