1. Management model, challenges, and opportunities for core facilities in research institutes Buenos Aires March2015

2. Founded in 2000 31 groups + 6 core facilities 410 staff 73% foreigners Budget: 30M€ (49% core – National and local government; 51% external) Position 9 worldwide Q1, Health - Scimago Reports (2007-2011) Severo Ochoa center of Excellence THE CRG IN A NUTSHELL

3. CRG STRATEGIC GOALS EXCELLENCE IN SCIENCE TECHNOLOGY TRANSFER SCIENCE & SOCIETY FOREFRONT TECHNOLOGY ADVANCED TRAINING INTERNATIONAL COLLABORATION

4. The Core Facilities constitute the Institute’s centralized scientific research infrastructure and allow scientists shared access to sophisticated and expensive technologies that would be hard or impossible to set up in each research group independently. They are meant to be a meeting point for scientists from different institutes and disciplines, to foster exchange and integration of expertise, and to create and conduct interdisciplinary projects. CORE FACILITIES: MISSION

5. Provide the researchers with the BEST POSSIBLE SERVICE 1.Be state-of-the-art with respect to technologies 2.Generate optimal benefit with the available resources (work towards a larger degree of auto-sustainability and capacity to re-invest in cutting-edge technologies) 3.Provide multi-disciplinary training to the next generation of scientists CORE FACILITIES: MISSION

6. Provide the researchers with the BEST POSSIBLE SERVICE 1.Be state-of-the-art with respect to technologies 2.Generate optimal benefit with the available resources (work towards a larger degree of auto-sustainability and capacity to re-invest in cutting-edge technologies) 3.Provide multi-disciplinary training to the next generation of scientists Become a “Reference Centre for Technology” CORE FACILITIES: MISSION

7. FOREFRONT TECHNOLOGIES

8. Core Facilities Meeting CRG Executive Board CRG Faculty Mixed Commission Secretary 2 Finance Officers ORGANIZATION OF THE PROGRAMME Board of Trustees Director Head of Core Facilities SIT Histology Screening and Protein Technologies FACS Bio- informatics Advanced Light Microscopy Proteomics Genomics Joint Facilities with the UPF

9. Yearly online User Satisfaction Survey Individual User Advisory Committees for each Core Facility, 4-5 expert users: Provide feedback on the quality of the service Guide the Facility in terms of technology development/implementation. Communication with the users during the facilities’ daily operations: Initial project discussions Status updates during course of the projects Follow-up and discussion of the data USER FEEDBACK

10. Courses@CRG Technology Symposia Internal training Participation in UPF/CRG Masters and PhD courses Videoclips on website TRAINING

11. FINANCIALS Daily operations and R&D Competitiv e Grants Trustees External Users CRG Research Groups Competitive Grants Trustees Core Facilities Service We work with two separate budgets: R&D and services Each core facility is given a budget for technology development and daily operations. CRG research groups receive an earmarked budget to be spent in Core Facilities.

12. FINANCIALS CRG core facilities operate according to full cost accounting principles. Full-cost accounting: Consumables Personnel: 80% of yearly working hours Equipment Depreciation: 5 years for laboratory equipment, 3 years for computational equipment 8-12 hours/day, yearly working days Equipment Maintenance/Repair: 8-12 hours/day, yearly working days General Structure = 20% of total cost 3 different prices: Internal (PRBB) = consumables + maintenance/repair + %personnel External Public = full cost External Private = full cost + negotiation

13. Keeping abreast of technologies Visibility / Reputation Avoid duplications Funding CHALLENGES and OPPORTUNITIES

14. TECHNOLOGIES Keeping abreast of technologies: expensive Visibility / Reputation Avoid duplications Funding

15. TECHNOLOGIES Keeping abreast of technologies: VERY expensive Visibility / Reputation Avoid duplications Funding

16. Keeping abreast of technologies Tech scouting and purchase Joint projects with providers and other companies Development in-house (dedicated personnel) TECHNOLOGIES

17. Keeping abreast of technologies Visibility / Reputation: International collaborations Avoid duplications Funding CHALLENGES and OPPORTUNITIES

18. over 284 publications with core facility contributions 80 co-authored publications, 11 of them as last author 130 out of 206 CRG last- author research papers with core facility contributions Core Facilities were involved in roughly 2/3 of the CRG publications COLLABORATIONS IN PUBLICATIONS CRG Core Facilities CRG Research Groups Bioinformatics Genomics Proteomics Microscopy BMS&PT

19. INTERNATIONAL COLLABORATIONS Reference site agreements with providers: Leica, Illumina, Thermo, ABSciex, Becton Dickinson International alliances: PRIME-XS, ESGI, EuroBioimaging, P4EU. 6 partners Sharing best practice Training Scouting new technologies Capacity sharing Funding 6 partners Sharing best practice Training Scouting new technologies Capacity sharing Funding 13 partners Promoting excellence Integration Attract talent, support mobility Sharing best practise in research and management 13 partners Promoting excellence Integration Attract talent, support mobility Sharing best practise in research and management

20. Keeping abreast of technologies Visibility / Reputation Avoid duplications: Agreements with other research centres Funding CHALLENGES and OPPORTUNITIES

21. AGREEMENTS WITH RESEARCH CENTRES UPF (Joint facilities) VHIR (Alliance pricing) CCiTUB (Use of complementary facilities) ICFO (Super-resolution Light Nanoscopy Alliance) BSC (High-Performance Computing cluster) Spanish networks: Remoa, ProteoRed

23. CHALLENGES and OPPORTUNITIES Keeping abreast of technologies Visibility / Reputation Avoid duplications Funding: National funding (decreasing), H2020 (translation and innovation)

24. Funding Partner with companies (H2020 innovation projects) Collaborate with Hospitals (H2020 translation projects) Negotiate with providers (discounts and participation in projects) Private funding for social projects FUNDING

27. STATE-OF- THE-ART AUTO- SUSTAINABILITY Become a “REFERENCE CENTRE FOR TECHNOLOGY”

29. ÒSCAR FORNAS FACS EDUARD SABIDÓ PROTEOMICS HEINZ HIMMELBAUER GENOMICS TIMO ZIMMERMAN MICROSCOPY CARLO CAROLIS SCREENING and PROTEIN TECH JULIA PONOMARENKO BIOINFORMATICS

31. 40 people 3 administrative members not formally belonging to the programme PERSONNEL FunctionFundingNationalities