1. Integrating OpenClinica and TrialVista CTMS Data Using Comprehend Clinical

2. www.comprehend.com Agenda Introductions TrialVista Overview Comprehend Clinical Overview Why use Comprehend Clinical with OC? Comprehend Clinical Demonstration Questions

3. www.comprehend.com Introductions Rick Morrison, Founder, CEO Comprehend rmorrison@comprehend.com 10+ years developing clinical analytics software used by FDA and top pharma. Hunter Walker, CTO Atlantic Research Group hwalker@atlanticresearchgroup.com 13 years within Clinical Operations (CRO and biotech)

4. www.comprehend.com TrialVista CTMS Overview TrialVista is a Clinical Trial Management System (CTMS) that allows clients to better control and manage their clinical development programs. Built using Intuit’s Quickbase (SaaS) No programming required Modular Design Easy to Use Flexible API Comprehensive Reporting Automatic Email Notifications

5. www.comprehend.com TrialVista Modules Investigator DatabaseRegulatory Management IP ManagementMonitoring Visit Reports Project ManagementPatient Management Safety SurveillancePatient Reported Outcomes Budget and Finance (Inv Payments)Central Document Repository Study Q&ACRA Visit Calendar CRF Tracking (paper-based studies)Help Request Manager

6. www.comprehend.com Problem Study 1 Study 2 Study 3 There are a ton of different data collection systems now, even within a single study. EDC, CTMS, ePRO, Lab, Safety, and more!

7. www.comprehend.com Email & SMS Alerts Mobile Devices Standard Web Browser Intranet Portals Comprehend Overview

8. www.comprehend.com Seamless actionable insights in real time

9. www.comprehend.com Comprehend is not just BI, it substitutes or leverages: Data Warehouses ETL tools BI tools Custom Programs Teams of Programmers Collaboration suites Discrepancy Systems Clinical Trial Management Systems (CTMS)

10. www.comprehend.com Features Ad-hoc reporting Role-based dashboards Intelligent click-through Filters and subsets Collaboration Reports

11. www.comprehend.com Core Technology: LiveET™ Inference Mapping™ Automated schema-negotiation Pluggable domain-specific typing system Data Metadata Config

12. www.comprehend.com Why Implement Comprehend Clinical with OpenClinica? Provides sponsors, CROs, and sites access to OC data via a view-only study portal Enables users to easily create OpenClinica Reports Compare visit data in OC with the Patient Schedule in TrialVista Show OC data entry status in relation to investigator payments

13. www.comprehend.com Demonstration

14. www.comprehend.com Future Comprehend Features

15. www.comprehend.com Questions?