1. DIFFERENTIATION OF IRON DEFICIENCY FROM ANEMIA OF INFLAMMATORY DISEASE

2. ANEMIA PCV TP PCV TP N

3. ANEMIA AND MICROCYTOSIS DIFFERENTIAL DIAGNOSES?

4. ANEMIA AND MICROCYTOSIS DIFFERENTIAL DIAGNOSES: –LIVER DISEASE (SHUNT, CIRRHOSIS) –ANEMIA OF CHRONIC DISEASE –SHIBA INU, AKITA (CHOW?) –IRON DEFICIENCY –(COPPER DEFICIENCY) –(ALUMINUM TOXICITY)

7. IRON DEFICIENCY ANEMIA ANEMIA OF INFLAMMATORY DISEASE MICROCYTIC LIVER DISEASE HCT MCV MCHC RDW RETICULOCYTE COUNT SERUM IRON TIBC SERUM FERRITIN BONE MARROW IRON

8. IRON METABOLISM

9. IRON DISTRIBUTION WITH DEFICIENCY, STORED IRON IS DEPLETED FIRST.

10. IRON ABSORPTION Bowel lumenFe mucosal cell portal circulation Fe storage

11. TRANSPORT IN PLASMA TRANSFERRIN PRODUCTION CONTROLLED BY LIVER IRON STORES

12. IRON STORAGE “LABILE Fe POOL” FERRITIN TRANSFERRIN HEMOSIDERIN MPS CELL

13. IRON DEFICIENCY HEMATOLOGY –MCV –MCHC –SCHISTOCYTES –THROMBOCYTOSIS

14. TESTS OF IRON METABOLISM RBC HISTOGRAM RELATIVE FREQUENCY CELL VOLUME NORMAL IRON DEFICIENCY

15. TESTS OF IRON METABOLISM SERUM IRON

16. TIBC TOTAL IRON BINDING CAPACITY APPROXIMATES TRANSFERRIN CONCENTRATION

17. PERCENT SATURATION SERUM IRON TIBC PERCENT SATURATION = SERUM IRON TIBC

18. TESTS OF IRON METABOLISM BONE MARROW IRON STORES –PRUSSIAN BLUE STAIN –HEMOSIDERIN STORES

19. TESTS OF IRON METABOLISM SERUM FERRITIN

20. DISORDERS OF IRON METABOLISM IRON DEFICIENCY –YOUNG VS. OLD PATIENTS –EVALUATION HEMATOLOGY SERUM IRON TIBC/ % SAT. BM IRON SERUM FERRITIN

21. ANEMIA OF CHRONIC DISEASE AKA: ANEMIA OF INFLAMMATORY DISEASE (ACD, AID) –FUNCTION –MECHANISMS

22. ANEMIA OF CHRONIC DISEASE –EVALUATION HEMATOLOGY SERUM IRON TIBC/ % SAT BM IRON SERUM FERRITIN

24. IRON DEFICIENCY ANEMIA ANEMIA OF INFLAMMATORY DISEASE MICROCYTIC LIVER DISEASE HCTMODERATE TO MARKED ANEMIA MILD TO MODERATE ANEMIA NORMAL TO MILD ANEMIA MCVMILD TO MODERATELY LOW NORMAL TO MILDLY LOW MCHCNORMAL TO MARKEDLY LOW NORMALNORMAL TO MILDLY LOW RDWMILD TO MODERATE INCREASE NORMAL TO MILDLY DECREASED NORMAL TO MILDLY INCREASED RETICULOCYTE COUNT LOW TO MARKED INCREASE LOW SERUM IRONLOWNORMAL TO LOW TIBCNORMAL TO INCREASED NORMAL TO DECREASED SERUM FERRITINDECREASEDNORMAL TO INCREASED NORMAL BONE MARROW IRONDECREASED TO ABSENT NORMAL TO INCREASED