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Assessment of Iron Status

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Presentation on theme: "Assessment of Iron Status"— Presentation transcript:

1 Assessment of Iron Status
David L. Gee, PhD FCSN 442 Nutrition Assessment Laboratory 1

2 Iron Status Stage one - iron deficiency Depletion of iron stores
Ferritin - primary storage form of iron Serum ferritin reflects tissue levels Low serum ferritin - early iron deficiency 16

3 Iron Status Stage Two Iron Deficiency Iron deficiency without anemia
Transferrin - serum iron transport protein Serum iron reflects transferrin iron Each transferrin protein can bind two iron atoms 17

4 Transferrin Normal transferrin saturation (TS)= 30%
Total Iron Binding Capacity (TIBC) add excess iron to serum to saturate transferrin, remove unbound iron, measure total iron = TIBC TS = [(serum iron)/TIBC]*100 low TS = stage 2 iron deficiency 18

5 Iron Status Stage Three Iron Deficiency Iron deficiency anemia
low iron stores (low serum ferritin) low transferrin saturation microcytic hypochromic anemia 19

6 Hemoglobin Widely used diagnosis of late stage iron deficiency
Table 9-6 cutoff values for Hgb based on 5th pct, NHANES II hemodilution during early pregnancy early exercise training 20

7 Hematocrit Packed RBC cell volume
%HCT = % of RBC making up whole blood volume Manual measurement Automated blood counters calculated from RBC count and MCV high due to dehydration 21

8 Mean Corpuscular Volume
MCV average size of RBC elevated with: folate and B12 deficiency decreased with: iron deficiency 22

9 Mean Corpuscular Hemoglobin
MCH = amount of hemoglobin in RBC picograms per cell Mean corpuscular hemoglobin concentration (MCHC) average concentration of HB in RBC g/l 23



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