1. Fast ConvenienceEfficient Economic Which One ？

2. 如何查阅、筛选和获取高质量文献 Library of CAMS/PUMC 李 越 Apr. 18, 2012

3. What is the Literature? How to find ? How to evaluate ? How to read ? How to analysis ? How to manage ?

4. About the Literature

5. Come from Study (evidence)  Original Randomized Controlled Trials(RCT) Cohort Study Retrospective Study(case control) ……

6. Come from Study (evidence)  2nd Systematic Reviews Meta Analysis Clinical Practice Guideline （ CPG ） ……

7. Come from Study (evidence)  3rd News Meeting Bibliography Database ……

8. Level of Study (evidence)

9. About the Literature √

10. About Search -PubMed

11. NCBI （ National Center for Biotechnology Information ）  General Introduction Established on 1988, as a division of the National Library of Medicine (NLM) at the National Institutes of Health (NIH). Http://www.ncbi.nlm.nih.gov

12. NCBI （ National Center for Biotechnology Information ） General Introduction Conducts research on fundamental biomedical problems at the molecular level using mathematical and computational methods Maintains collaborations with several NIH institutes, academia, industry, and other governmental agencies Fosters scientific communication by sponsoring meetings, workshops, and lecture series Supports training on basic and applied research in computational biology for postdoctoral fellows through the NIH Intramural Research Program

13. NCBI （ National Center for Biotechnology Information ） General Introduction Engages members of the international scientific community in informatics research and training through the Scientific Visitors Program Develops, distributes, supports, and coordinates access to a variety of databases and software for the scientific and medical communities Develops and promotes standards for databases, data deposition and exchange, and biological nomenclature

14. NCBI （ National Center for Biotechnology Information ） Entrez ( Cross-Database Search System ) It is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at NCBI website.

16. NCBI （ National Center for Biotechnology Information ）

17. General Introduction  Over 20 million citations from MEDLINE (1966-) and additional life sciences journals (1865-)  MEDLINE + PreMEDLINE + HyperLink

18. General Introduction  More than 80 countries,50 languages, 23.7 thousand journals  It`s FREE !! HOW to USE

20. Search Fields Text WordsMeSH Title / Abstract Words AuthorAffiliationPublication Date IssueLanguageSubstance Name Page No.EC/RC No.Publication Type Journal TitleSubheadingsUnique Identifiers Volume…………

21. Boolean Search  AND  OR  NOT

22. How do I search PubMed?  Identify the key concepts for your search.  Enter the terms (or key concepts) in the search box.  Click “Search” to run this search in PubMed.

23. Sample  胃癌 Stomach Cancer Stomach Tumor Stomach Tumour Stomach Neoplasm(s) …………

24. Stomach Cancer OR Stomach Tumor OR Stomach Tumour OR Stomach Neoplasm?

26. Journal Title 、 Publication Date Title Words Authors Affilication Abstract Unique Identifiers Search the same topic articles from Title\Abstract\MeSH

27. FullText HyperLink LinkOut

31. WHY there are so many articles not I want? The garbage articles make me boring!!

32. More Exactly?  Stomach Cancer Stomach Cancer Stomach Tumor Stomach Tumour Stomach Neoplasm(s) ………… Stomach Neoplasms MeSH

33. MeSH (Medical Subject Headings)  Controlled vocabulary of biomedical terms that is used to describe the subject of each journal article in MEDLINE  There are 26,142 descriptors in 2011 MeSH

35. 标 签标 签

36. Controlled Standardized

38. Stomach Cancer

41. Subheadings  Narrow the specific focus of a main topical heading to a particular aspect of the subject.  There are 83 topical qualifiers  http://www.nlm.nih.gov/mesh/topsu bscope.html

43. Tips  Operation—Surgery (Subheadings)  Drug/adverse effects  Therapy Method/adverse effects  Disease/complication

44. Sample Therapy or Nursing on Stomach Cancer

47. 主要主题词

49. 不扩展下位词

50. How to focus on my search? Limits

53. Tips  Clinical Queries  Single Citation Matcher

57. If I only know the title, how to search the article? Single Citation Matcher

60. Sample  2008;5;387-?

61. 2008 5 387

63. Can I save my results & habits? My NCBI

72. 过 滤 器过 滤 器

77. meta

78. Recommend

80. F1000 (Faculty of 1000)  Continuously updated selections and evaluations of the most important articles  Attributed opinions and expert knowledge from global leaders in biology and medicine  Site customization and email alerts based on user interests  Recommendations and interpretations based on the article's merits, not the journal's

83. Recommended （ 6-7 ） Must Read （ 8-9 ） Exceptional 10+

87. About the Literature √ About search √

88. About Evaluation

89. Evaluation  F1000 or F1000m  SCIe  Jadad Scale  ……

95. About Read

96. Read  Title  Material & Method  Outcome  Discussion  ……

97. Jadad Scale 97 Jadad AR, Moore RA, Carrol D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary [J] Control Clin Trials, 1996, 17:1–12.

98. Jadad Scale Grade  Full Mark: 5  High Mark : ≥3  Low Mark: ＜ 2 : easy, abroad : lack of allocation concealment

99. Jadad + Schulz  Adequate  Inadequate  Unclear http://www.cochrane-handbook.org

100. e.g. Title Randomized clinical trial of intravenous soybean oil ( 豆油 )alone versus soybean oil plus fish oil emulsion ( 乳剂 )after gastrointestinal cancer surgery. Jiang ZM, Wilmore DW, Wang XR, et al. Br J Surg. 2010, 97(6):804-809.

101. e.g. 101 Reference: Jiang ZM, Wilmore DW, Wang XR, et al. Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery. Br J Surg. 2010, 97(6):804-809. Material & Method R DB

102. Follow-up

103. e.g. Jadad – 随机： 2 分（文中描述了随机序列产生方法且方法恰当） – 双盲： 2 分（文中描述了实施双盲的方法且盲法恰当） – 退出与失访： 1 分（文中对退出的例数和理由进行了详细 描述，无失访） 此文总得分为 5 分，属高质量研究 103

104. e.g. 104 Reference: Jiang ZM, Wilmore DW, Wang XR, et al. Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery. Br J Surg. 2010, 97(6):804-809. Material & Method

105. e.g. Schulz 隐蔽分组 – 此文中产生随机序列者（统计室）和决定分配序别 者（配药护士）均未参与纳入患者的工作，也未参 与研究过程以及结果的测量和分析， 此文中隐蔽分组为充分（ Adequate ） 105

106. About the Literature √ About search √ About Evaluation √ About Read √

107. About Analysis

108. How can I analysis the articles?        

109. GoPubMed  Based on PubMed Database  Gene Ontology AND MeSH  Analysis  It`s FREE!! www.gopubmed.com

111. and 1000000 [maxdocs]

119. Where r u?

120. So Many PDFs, How to Manage them? Management Software

121. About Management

125. www.library.imicams.ac.cn

127. 循证医学数据库 Best Practice Cochrane MICROMEDEX Pier

135. www.library.imicams.ac.cn

137. What is the Literature? How to find ? How to evaluate ? How to read ? How to analysis ? How to manage ?

138. 谢 谢谢 谢