1. BBSRC National Centre of Virology The Pirbright Institute and CL4 Facilities Dr Mike Johnson Head of Estates SRO Development Programme

2. A Brief, Terrifying History of Viruses Escaping From Labs: How well-intentioned research with dangerous pathogens could put people at risk. The Ebola Strain Links African Outbreak To A Lab Escape CDC Closes Labs After Anthrax, Bird Flu, Smallpox, and Who Knows What Else Escaped New lab incidents fuel fear, safety concerns in Congress Bio-Unsafety Level 3: Could the Next Lab Accident Result in a Pandemic? Threatened pandemics and laboratory escapes: Self-fulfilling prophecies Pirbright lab told to improve safety over foot and mouth UNWANTED HEADLINES!

3. Reviews Series of Reports and recommendations re the future of the Pirbright facilities - HSE (2007) - Spratt (2007) - Callaghan (2007) - Anderson (2008) - House of Common Review (2008) - Beringer (2008) - H&S Biosecurity (2014) “Rebuild the Pirbright facility….fit for purpose”

4. In 2001 there was a major FMD outbreak event in the UK ….. Cost £8B+ Formative idea of a National Centre for Virology including relocation of science from VLA Weybridge….2005 Pirbright Site Redevelopment Plan 2007 another FMD outbreak: £200M focus on the infrastructure of the Institute…. Requirement….

5. NEW OLD Transition projects – building assurance Drainage

6. OLD NEW Transition projects – Interim Laboratory

7. OLDNEW Transition projects – Effluent Treatment

8. Science strategy: work on viruses only : extend to interface between animals and humans and work on zoonotic agents. Design of Plowright building – CL4 containment facility All the features: HVAC/pressure cascades, Effluent treatment, sealability, generic labs – flexibility CL3 labs on GF East- ACDP3 agents Science Strategy - Design

9. The Big Change project: Plowright Building August 2010 construction started 2009

10. The Big Change project: Plowright Building

14. The BBSRC National Virology Centre The Plowright Building Jan 2014

15. Acknowledgements