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Published byCadence Fellows Modified over 9 years ago
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Mechanics of ventilation How the lung is supported and moved
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Pneumothorax of right lung
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Rotation axis ribs
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Static recoil Interpleural pressure Air flow inspexsp Interpleural pressure Tidal volume
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P=T/r ↑r ↓T P = P ↓CL↓CL Dipalmitol fosfatidil cholin + protein
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Alveoli are larger at the apex (upper panel) than base (lower)
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∆V ∆P C = ∆V / ∆P
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∆P ∆V. R=∆P / ∆V.
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Number of airways increases rapidly with generation
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Mechanism of dynamic compression
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Work done on the lung during breathing
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Transport of gas from alveoli to blood
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Gas Membrane blood 0.5 μm
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Very thin blood-gas barrier
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Limitation by perfusion Limitation by diffusion
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Respiration at the limit: surviving on the summit of Mt Everest
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Highest altitudes attained in the last century
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Maximum oxygen uptake at increasing altitudes
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Climbers Ranked by their Hypoxic Ventilatory Response
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Alveolar Pco 2 at Extreme Altitudes
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Pulmonary Gas Exchange on the Everest Summit
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O 2 Dissociation Curves in High-Altitude Mammals
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Decrease of barometric pressure with altitude
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Climber on the Everest Summit
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Polycythemia at 4600 m altitude Hemoglobin concentration 19.8 g/dl Arterial PO 2 45 mm Hg O 2 saturation 81% O 2 concentration 22.4 ml/dl
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D LO2 = V O2 / P AO2 P c O2 D LCO = V CO / P ACO Time of blood flow through pulmonary capillary
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