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Omega-3 fatty acid intake effect on allergy severity MBA 555 Fall 2011 Rebecca Fan.

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Presentation on theme: "Omega-3 fatty acid intake effect on allergy severity MBA 555 Fall 2011 Rebecca Fan."— Presentation transcript:

1 Omega-3 fatty acid intake effect on allergy severity MBA 555 Fall 2011 Rebecca Fan

2 Introduction Epidemiological research has indicated that allergy disease is triggered by the combination of both genetic and environmental factors Few studies has reported that intake of omega- 3 fatty acid could potentially reduce the blood pressure and allergy severity level Omega-3 supplementation during pregnancy and lactation could decrease the risk of childhood asthma; however the evidence was not conclusive across different studies

3 Introduction Serum IgE level has been recognized as the surrogate for allergy severity level measurement Variations of normal total serum IgE can range from 150 to 1,000 UI/ml; however the acceptable upper limit is usually between 150 and 300 UI/ml

4 Objectives Investigate the relationship between allergy severity level reduction and omega-3 intake Understand how other factors such as age, gender, height, weight, smoking and prior history of allergy could impact the effect between omega-3 intake and serum IgE level H 0 : Daily omega-3 intake(g/d) has a significant effect on serum IgE level(UI/ml), either positive or negative (two-sided test)

5 Data source and study population De-identified data from an allergy treatment clinical trial (on-going) 46 individuals with complete demographic information collected including: age, height, weight, gender (1=male;2=female), smoking status (1=yes;0=no), and previous allergy history (1=yes;0=no)

6 Analysis Software tool: WinORS Models- Ordinary Least Square (OLS) - Multiplicative model was applied to log transformed data in order to estimate the impact of % change in serum IgE level in responding to % change in omega-3 intake - Weighted Least Square (WLS)

7 Result - OLS White's Test for Homoscedasticity:P=0.14479

8 Result - OLS Normality test:P=0.987, Average VIF=1.491

9 Result – Multiplicative Model Elasticity parameter estimates:

10 Result – WLS Elasticity parameter estimates:

11 Conclusion and implication Elasticity of IgE level = 6.764+ (-0.76)*omega- 3(g/d) + (-0.245)*SEX + (0.425)*PrevHis Recommendation for nutrition intake: 10% increase in daily omega-3 intake could help to reduce serum IgE level by 8% Gender variable suggested a protective effect for female (lower IgE level compare with same condition male), possibility because women in general are more health conscious than man

12 References Ann Med Interne (Paris). 1985;136(5):419-22. Laurent J et al. How to define the normal level of serum IgE in adults? Acta Paediatr. 2009 Sep;98(9):1461-1467. Furchjelm C et al. Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. BJOG 2011 Jul;118(8):916-25. doi: 10.1111/j.1471-0528.2010.02846.x. Klemens CM et al. The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: a systematic review. Fur M Med Res. 2009 Dec 7;14 Suppl 4:248-54. Wilczyska-Kwiatek A et al. Asthma, allergy, mood disorders, and nutrition. Allergy. 2009 Jun;64(6):840-8. Epub 2009 Apr 7. Anandan C et al. Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis.

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