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Biochemistry Lecture 1.

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Presentation on theme: "Biochemistry Lecture 1."— Presentation transcript:

1 Biochemistry Lecture 1

2 Bloom’s Taxonomy Richard C. Overbaugh, Lynn Schultz Old Dominion University

3 Student Objectives for this course
Calculate bioenergetic parameters and evaluate carbon molecules reactions Reproduce and explain key metabolic processes: glycolysis, TCA cycle, electron transport and oxidative phosphorylation, fatty acid oxidation Analyze protein structure and function and evaluate different methods used to assess and test structure and function Trace key metabolites through key pathways, design experiments to test carbon flux Compare and contrast modes of metabolism regulation and judge the effects of different modes

4 Biochemistry is the chemistry of Living Systems
The Chemistry of Carbon and Water Themes for this course: The transformation of energy Levels of complexity

5 Cells

6 Cells

7 Levels of Complexity Lipids

8 The Inner Life of the Cell

9 Why Carbon What can we learn from this?
Bond Strength (kJ/mol) C – C 347 – 356 C = C 611 837 C – O 336 C – H 356 – 460 Si – Si 230 Si – O 368 O – O 146 O = O 498 N – N 163 N = N 418 946 What can we learn from this? C – C bond is stronger than C – O Stable in oxygen rich environment! Two C – C bonds are stronger than one C = C Chains are stable! C – H bond is strong Hydrocarbons stable at room temperature!

10 Important Functional Groups
Alcohol Thiol Amine Ether Thioether Peroxide Disulfide Aldehyde Ketone Carboxylic acid Ester Anhydride Amide Thioester Phosphate Phosphoester Phosphoanhydride


12 Carbon and Functional Groups

13 Other biomolecules PEP NADP+ Phosphatidylcholine

14 Bioenergetics Cell Reactants Products Steady State = constant flux
Structural differences between reactants and products Concentration differences between reactants and products

15 Water

16 Hydrogen Bonds

17 Water

18 Colligative Properties

19 pH pH = -log[H+]

20 Acids

21 Buffers

22 Hendeson Hasselbalch Equation
HA H+ + A-

23 Summary Biochemistry is the chemistry of living things
Which is the chemistry of carbon and water Carbons unique bonding properties Water: hydrogen bonds and ionization Buffers and pH

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