2 Bloom’s TaxonomyRichard C. Overbaugh, Lynn Schultz Old Dominion University
3 Student Objectives for this course Calculate bioenergetic parameters and evaluate carbon molecules reactionsReproduce and explain key metabolic processes: glycolysis, TCA cycle, electron transport and oxidative phosphorylation, fatty acid oxidationAnalyze protein structure and function and evaluate different methods used to assess and test structure and functionTrace key metabolites through key pathways, design experiments to test carbon fluxCompare and contrast modes of metabolism regulation and judge the effects of different modes
4 Biochemistry is the chemistry of Living Systems The Chemistry of Carbon and WaterThemes for this course:The transformation of energyLevels of complexity
9 Why Carbon What can we learn from this? BondStrength (kJ/mol)C – C347 – 356C = C611837C – O336C – H356 – 460Si – Si230Si – O368O – O146O = O498N – N163N = N418946What can we learn from this?C – C bond is stronger than C – OStable in oxygen rich environment!Two C – C bonds are stronger than one C = CChains are stable!C – H bond is strongHydrocarbons stable at room temperature!
10 Important Functional Groups AlcoholThiolAmineEtherThioetherPeroxideDisulfideAldehydeKetoneCarboxylic acidEsterAnhydrideAmideThioesterPhosphatePhosphoesterPhosphoanhydride