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Erythroplasia of Queyrat: Coinfection with Cutaneous Carcinogenic Human Papillomavirus Type 8 and Genital Papillomaviruses in a Carcinoma In Situ  Ulrike.

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Presentation on theme: "Erythroplasia of Queyrat: Coinfection with Cutaneous Carcinogenic Human Papillomavirus Type 8 and Genital Papillomaviruses in a Carcinoma In Situ  Ulrike."— Presentation transcript:

1 Erythroplasia of Queyrat: Coinfection with Cutaneous Carcinogenic Human Papillomavirus Type 8 and Genital Papillomaviruses in a Carcinoma In Situ  Ulrike Wieland, Sandra Jurk, Sönke Weißenborn, Herbert Pfister  Journal of Investigative Dermatology  Volume 115, Issue 3, Pages (September 2000) DOI: /j x Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 EQ on the glans penis. Patient H is shown before treatment. Anamnesticly the 64 y old patient had had a duration of disease of 3 y. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 EQ is histologically similar to BD. The HPV-positive EQ biopsy (patient H) shows thickening of the epidermis with dyskeratotic cells. Keratinocytes exhibit a partial loss of polarity, atypia, and atypical mitoses. The upper dermis shows infiltrates of lymphocytes, histiocytes and plasma cells. Koilocytosis could not be detected (hematoxylin–eosin; scale bar: 25 μM). Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

4 Figure 3 HPV8 LCR and E6 gene mutations are prevalent in EQ. HPV8 nucleotide exchanges found in EQ samples in the 3′ part of the HPV8 LCR and in the 5′ part of the E6 gene (top line) are shown in comparison to the HPV8 reference sequence (middle line) (Fuchs et al. 1986) and to a HPV8 E6 variant named 8a5 (bottom line) (Deau et al. 1991).The latter two were derived from EV patients. Conserved positions are indicated by dashes. Mutations shown in capital letters and marked by Δ were found in all EQ clones investigated (LCR: 10 clones of three patients; E6: 14 clones of four patients). Mutations shown in small letters were only found in individual EQ clones, respectively. Nucleotide exchanges that led to mutations in the deduced EQ E6 amino acid sequences are marked by an asterisk. The numbers indicate the nucleotide positions of the HPV8 complete genome (Fuchs et al. 1986). The GenBank accession number of a representativeHPV8EQ sequence (patient E, clone 3) is AF Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

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