1. by David W. Bahler, John A. Miklos, and Steven H. Swerdlow
Ongoing Ig Gene Hypermutation in Salivary Gland Mucosa-Associated Lymphoid Tissue-Type Lymphomas
by David W. Bahler, John A. Miklos, and Steven H. Swerdlow
Blood
Volume 89(9):
May 1, 1997
©1997 by American Society of Hematology

2. David W. Bahler et al. Blood 1997;89:3335-3344
©1997 by American Society of Hematology

3. David W. Bahler et al. Blood 1997;89:3335-3344
©1997 by American Society of Hematology

4. Deduced amino acid sequences of lymphoma V genes.
Deduced amino acid sequences of lymphoma V genes. Differences of the VH and VL consensus sequences from the most closely related germline genes are shown in (A) and (B), respectively, as upper case letters or are underlined in the J regions. The locations of silent mutations in the nucleic acid sequences are indicated with lower case letters.
David W. Bahler et al. Blood 1997;89:
©1997 by American Society of Hematology

5. Intraclonal heterogeneity of lymphoma V genes.
Intraclonal heterogeneity of lymphoma V genes. The four VL and 10 VH clones sequenced from case HA are shown in (A) and (B), respectively, compared with the proposed germline genes. VH clones HC6, HC8, HC9, and HC10 were isolated from the lymph node specimen, while the others were derived from the parotid gland specimen. Replacement mutations are in upper case, while silent mutations are in lower case. Mutations not common to all of the VH or VL sequences are bolded and also listed in Table 4 along with similar mutations identified in the other lymphoma V genes. Individual clones referred to in the text are prefixed with the identifying patient letters, eg, HAHC10 refers to clone HC10 from patient HA.
David W. Bahler et al. Blood 1997;89:
©1997 by American Society of Hematology

6. Lymphoma nucleotide sequences compared with germline D segments.
Lymphoma nucleotide sequences compared with germline D segments. The lymphoma VH CDR3 regions are shown up to but not including the JH segments indicated in Fig 2.
David W. Bahler et al. Blood 1997;89:
©1997 by American Society of Hematology