1. Fig. 2. Schematic diagram of the transport pathways of manchette
Fig. 2. Schematic diagram of the transport pathways of manchette. Intra-manchette transport (IMT) transfers structural and functional proteins via the microtubule tracks and motor proteins to the basal body region where they are stored. During intra-flagellar transport (IFT), proteins are transported from the sperm cell body to the tip of the flagellum and then back to the sperm head along the axonemal microtubules. Outward or anterograde movement (from the sperm head to the tail) is directly associated with microtubule motor kinesin-2 while inward or retrograde movement is related with dynein 1b. Abnormalities of IMT or IFT microtubule structure could lead to sperm head, neck and tail aberrations because of disruption of the protein delivery to the correct assembly site during spermiogenesis.
Fig. 2. Schematic diagram of the transport pathways of manchette. Intra-manchette transport (IMT) transfers structural and functional proteins via the microtubule tracks and motor proteins to the basal body region where they are stored. During intra- flagellar transport (IFT), proteins…
World J Mens Health Jan;38(1):