1. Immunotherapy of Blood Cancer Dr Andrejs Braun, MD, PhD, FHEA, FIBMS
Targeted Therapy and
Immunotherapy of Blood Cancer
Semester 2, Jan 2019 –Apr 2020
Module Leader:
Dr Andrejs Braun, MD, PhD, FHEA, FIBMS

5. The Nobel Prize in Physiology or Medicine 2018
"for their discovery of cancer therapy by inhibition of negative immune regulation."

6. Cancer Research UK research strategy
“We will invest in new funding schemes to support world-class research that will enable us to meet our ambitions.”
Strengthen existing funding
Invest in innovation
Support collaboration
Address big questions
Invest in people
Strategic awards
Boost immunology research

7. Cancer Research UK research strategy
6) Boost immunology research
More grants
More jobs
More PhD studentships

8. Aims – translational cancer research
Understand the latest molecular (targeted therapy) and immunotherapy [cancer immunology] approaches being applied to translational cancer research (the latest research driven treatment strategies for cancer patients).
Understand the critical contribution of the tumour microenvironment (eg., immune T cells, macrophages and stromal cells) towards tumour-promoting inflammation immune response (dynamically interconnected processes).
Understand the key cellular and molecular (genetic) processes affecting leukaemia and lymphoma cells.

9. Teaching team
John
Jeff
Jude
Bella
Jane
Andre
Serge

10. Teaching team Centre for Haemato-Oncology
Dr Andrejs Braun, Senior Lecturer
Prof John Gribben, Professor
Prof Jude Fitzgibbon, Professor
Dr Jeff Davies, Senior Clinical Lecturer
Dr Serge Krysov, Senior Lecturer
Dr Bela Wrench, Senior Clinical Lecturer
Centre for Haemato-Oncology

11. Syllabus
Hematological Malignancies, Cancer Stem Cells and Genetic Techniques in Translational Research (Prof Jude Fitzgibbon)
Molecular Biology of Hodgkin Lymphoma (Prof John Gribben)
Adoptive/Passive Cancer Immunotherapy (Prof John Gribben)
Stratified and Personalized Medicine (Prof Jude Fitzgibbon)
Targeted therapy of lymphoma (Dr Andrejs Braun)
Radioimmunotherapy (Dr Jane Sosabowski)
Immune tumour microenvironment (Dr Kevin Rouault Pierre)
Hematopoietic stem cell transplantation (Dr Jeff Davies)
Cell death in leukaemia and lymphoma (Dr Li Jia)
DNA vaccination (Dr Serge Krysov)
Chronic Lymphocytic Leukemia (John Gribben)
Practical Classes in the Haematology- Oncology laboratory (Marta Crespi Sallan)

12. Module details: teaching format
1 Unit module:
Total student study hours - 150
Contact time 30, Private Study Hours 120
Each 3h teaching session includes:
~ 1 hr formal lecture followed by
1 hr tutorial work with student presentations and Q&A & critical discussion.
1hr practical sessions: Molecular and cell biology techniques used for analysis of leukaemia/lymphoma patient samples
(Centre for Haemato-Oncology)

13. Module details: assessment
In course assessments (weighting 40%):
Individual tutorial paper presentation, Individual poster/viva/presentation, Examination weighting, 15%
Essay, Examination weighting 25%
Critically evaluate a new biological target, drug, or treatment for a hematological malignancy words max (excluding references and figure legends)

14. Module details: assessment
Final exam paper (weighting 60%):
30 x Multiple Choice Questions (MCQs, 35% of 60%) and
4 Short Answer Questions * (SAQs, 65% of 60%).
(* critical analysis of lecture content, further reading papers and current thinking in the field)

15. Module difficulty (ARCS)

16. Student module evaluation (ARCS)

17. Enjoy!