1. THE BRIGHAM AND WOMEN’S DEPARTMENT OF NEUROSURGERY (1913-2013)
Society of Neurological Surgery
Annual Meeting
Boston, MA
June 9, 2013
THE BRIGHAM AND WOMEN’S
DEPARTMENT OF NEUROSURGERY
( )
Neuroendocrine /Pituitary Center
ED LAWS, MD
Skull Base Center
OSSAMA AL-MEFTY, MD
IAN DUNN, MD PhD
Neurosurgical ICU and TBI
BILL GORMLEY, MD
Cerebrovascular Center
KAI FRERICHS, MD PhD
ROSE DU, MD PhD
ALI AZIZ-SULTAN, MD (10/2013)
Research Faculty
MARIANO VIAPIANO, PhD
JAKUB GODLEWSKI, PhD
AGNIESZKA BRONISZ, PhD
TED TENG, MD PhD
NATHALIE AGAR, PhD
BRUCE KRISTAL, PhD
XIN WANG, PhD
SEAN LAWLER, PhD
Functional NS
TRAVIS TIERNEY, MD PhD
Neuro-oncological Surgery
MARK JOHNSON, MD PhD
ALEXANDRA GOLBY, MD PHD
ELIZABETH CLAUS, MD MPH
E.A. CHIOCCA, MD PHD
Spine Center
MICHAEL GROFF, MD
JOHN CHI, MD PhD
YI LU, MD PHD (7/2013)

2. People 23 Faculty (15 NS and 8 scientists)
16 NS residents (3 PGY1; 3 PGY2; 2 PGY3-7)
5 Clinical Fellows (Skull base; Pituitary; Image-guidance; Endovascular; Spine)
42 Administration/Support Staff
96 research personnel

3. Chiefs of Service Harvey Cushing 1913-1932 Franc Ingraham 1932- 1964
Donald
Matson
John
Shillito
Harvey Cushing
Keasley
Welch
Peter
Black
Arthur
Day
John
Popp

4. Brigham Alum Academic Chairs
Howard
Eisenberg
UTMB, Maryland
Eben Alexander
Wake Forest
Don Long
Hopkins
David Kelly
Wake Forest
Dong H. Kim
UT Houston
Phil Stieg
Cornell
Ed Laws
GWU
Sam Al-Mefty
Arkansas
John Popp
Albany
John Tew
Cincinnati
Rich Ellenbogen
U. Washington
Rob Friedlander
Pittsburgh

5. Brigham alum in academia
Ian Johnson (MUSC)
Adel Malek (Tufts)
Don Matson (Brigham/BCH)
Ernest Matthews (NYU/Hopkins/Mt. Sinai/MGH)
Gordon McComb (USC)
Robert McLaurin (Cincinnati)
James McLennan (Cincinnati/Brown)
Parker Mickle (Florida)
Tom Moriarty (Louisville)
Larry Page (Miami)
John Park (NIH)
John Shillito (Brigham/BCH)
Phil Starr (UCSF)
John Walsh (Kentucky/UT/Tulane)
Simcha Weller (Tufts)
John Adler (Stanford)
Loren Amacher (Connecticut)
Edgar Bering (NIH/Georgetown)
Roc Chen (UT Houston)
Robin Davidson (U. Mass)
Kadir Erkmen (Dartmouth)
Kai Frerichs (Brigham)
August Giese (U. Missouri)
Alex Golby (Brigham)
Bruce Hendrick (Toronto)
Michael Jerva (u. Illinois)
Dennis Johnson (GWU/Penn St)

6. Brigham alumni in academia (since 2008)

7. Location of currently practicing NS Brigham Alumni

9. Quality metrics

10. The past: Neurosurgery Dept Location at Peter Bent Brigham Hospital -1913
The future: Neurosurgery Dept Location at:
Institute for the Neurosciences (2016)
Renovated PBB (2014)

11. Research funding

12. Teams

13. Neuro-oncology Programs in Neurosurgery
Harvey Cushing Neuro-oncology Laboratories (HIM 9)
Mariano Viapiano, PhD: Glioma microenvironment and invasion
Jakub Godlewski, PhD: microRNA biology in GBM
Agnieszka Bronisz, PhD: The tumor “secretome”
Sean Lawler, PhD: Glioma invasion
Nino Chiocca, MD PhD: Biologic therapeutics
Surgical Molecular Imaging Laboratory
Nathalie Agar, PhD: In vivo tumor metabolomics linked with imaging
Alex Golby, MD: Surgical imaging and brain mapping
Laboratory of Cellular and Molecular Neuro-oncology
Mark Johnson, MD PhD: Brain tumor genomics, stemness, invasion
Skull base tumor laboratory
Ian Dunn, MD PhD/ Ossama Al-Mefty, MD: Meningioma, pituitary adenoma, acoustic neuroma genomics
Brain tumor epidemiology
Liz Claus, MD PhD: Meningioma, GBM epidemiology and genetics
The pituitary/neuroendocrine program
Ed Laws, MD

14. Pituitary/Neuroendocrine Program
Edward R. Laws, Jr., MD, FACS and Colleagues
Now >500 new patients per year
530 operations with minimally invasive 3D endoscopic surgery
20+ transsphenoidal operations in the AMIGO 3T intraoperative MRI suite
Closing in on 6000 pituitary surgeries

15. Cases twice as likely as controls to report history of bitewing dental x-rays: OR=2.0 (1.4, 2.9)
Panorex at young age associated with increased risk: OR=4.9 (1.8, 13.2)
Counter to ADA guidelines, the majority of subjects reported receiving dental x-rays on a yearly or greater frequency

16. Tumor Cell Concentration
Anaplastic Oligodendroglioma
Tumor Cell Concentration
2HG Distribution
Histopathology score
2HG intensity
US Provisional Application No.: 61/747,330. Filed December 30, System and Method for Analysis of Bio-Metabolites Use in Image-Guided Surgery.
Santagata,S., Eberlin, L.S., Norton, N., Ide, J.L., Liu, X., Wiley, J.S., Orringer, D., Gill, K.K., Dunn, I.F., Dias-Santagata, D., Ligon, K.L., Jolesz, F.A., Golby, A.J., Cooks, R.G., and Agar, N.Y.R. (Submission) Metabolite-imaging mass spectrometry to guide brain surgery. 16

17. Cerebrovascular Surgery
Kai Frerichs, MD PhD
Endovascular
Neurosurgery
Rose Du, MD PhD
Cerebrovascular
Neurosurgery
Ali Aziz-Sultan, MD
Endovascular and
Open Vascular
Joining in October 2013
From Univ. of Miami
Siekert Award (AHA):
Platelet-activating
Factor in brain injury
NIH K08: Genomics
of human aneurysms

18. Neuro-apoptosis drug discovery lab
Xin Wang, PhD

19. Melatonin offers neuroprotection in chronic Huntington’s disease (HD),
Amyotrophic lateral sclerosis (ALS), and acute ischemic stroke
Melatonin slows disease progression in R6/2 HD mice. Melatonin delays disease onset 23% and extends survival 21%
J Neurosci ,
J Neurosci ,
C. Melatonin reduces
infract size in stroke
Stroke, ,
B. Melatonin
prolongs survival
and restores
Melatonin receptor
1A (MT1) in
mSOD1G93A
ALS mice
Neurobiol Dis.
, 26-35
Melatonin also prevents mitochondrial death pathways
CNS Neurosci Ther ,
PNAS, , 19

20. Spine Surgery Michael Groff, MD Starting in July 2013 John Chi, MD MPH
Chairman Joint Section
of Spine and Peripheral
nerve
Starting in July 2013
Yi Lu, MD PhD
John Chi, MD MPH
Harvard Catalyst Award

21. Functional Neurosurgery
Travis Tierney, MD PhD

22. Neurocritical Care William B Gormley, MD, MPH
Director of Neurosurgical Critical Care
Brigham & Women’s Hospital
Harvard Medical School
Board Certification:
American Board of Neurological Surgeons:
Neurosurgery
American Board of Surgery:
Surgical Critical Care
Neurosurgical Training Pathway to Critical Care Certification
Work together with AANS to develop two tier certification for Neurosurgery trainees
Level I
Ability to take care of personal patients in an ICU setting
Level II
Fully certified Critical Care practictioner

23. Mitochondrial Injury and function
Bruce Kristal, PhD

24. Controlled Cortical Impact
Kristal Laboratory and Collaborators
Imaging Biomarkers of TBI
Rat mTBI Models
Weight-Drop
Fluid Percussion
Controlled Cortical Impact
Mitochondrial
Targeted
Neuroprotection X
Fluid Biomarkers of TBI
Integrated
Biomarkers
of mTBI
Metabolomics and
Lipidomics

25. Thank you! Centennial of the founding of the Department
Of Neurosurgery at the Brigham and Women’s
Hospital
( )