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THE BRIGHAM AND WOMEN’S DEPARTMENT OF NEUROSURGERY ( )

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Presentation on theme: "THE BRIGHAM AND WOMEN’S DEPARTMENT OF NEUROSURGERY ( )"— Presentation transcript:

1 THE BRIGHAM AND WOMEN’S DEPARTMENT OF NEUROSURGERY (1913-2013)
Society of Neurological Surgery Annual Meeting Boston, MA June 9, 2013 THE BRIGHAM AND WOMEN’S DEPARTMENT OF NEUROSURGERY ( ) Neuroendocrine /Pituitary Center ED LAWS, MD Skull Base Center OSSAMA AL-MEFTY, MD IAN DUNN, MD PhD Neurosurgical ICU and TBI BILL GORMLEY, MD Cerebrovascular Center KAI FRERICHS, MD PhD ROSE DU, MD PhD ALI AZIZ-SULTAN, MD (10/2013) Research Faculty MARIANO VIAPIANO, PhD JAKUB GODLEWSKI, PhD AGNIESZKA BRONISZ, PhD TED TENG, MD PhD NATHALIE AGAR, PhD BRUCE KRISTAL, PhD XIN WANG, PhD SEAN LAWLER, PhD Functional NS TRAVIS TIERNEY, MD PhD Neuro-oncological Surgery MARK JOHNSON, MD PhD ALEXANDRA GOLBY, MD PHD ELIZABETH CLAUS, MD MPH E.A. CHIOCCA, MD PHD Spine Center MICHAEL GROFF, MD JOHN CHI, MD PhD YI LU, MD PHD (7/2013)

2 People 23 Faculty (15 NS and 8 scientists)
16 NS residents (3 PGY1; 3 PGY2; 2 PGY3-7) 5 Clinical Fellows (Skull base; Pituitary; Image-guidance; Endovascular; Spine) 42 Administration/Support Staff 96 research personnel

3 Chiefs of Service Harvey Cushing 1913-1932 Franc Ingraham 1932- 1964
Donald Matson John Shillito Harvey Cushing Keasley Welch Peter Black Arthur Day John Popp

4 Brigham Alum Academic Chairs
Howard Eisenberg UTMB, Maryland Eben Alexander Wake Forest Don Long Hopkins David Kelly Wake Forest Dong H. Kim UT Houston Phil Stieg Cornell Ed Laws GWU Sam Al-Mefty Arkansas John Popp Albany John Tew Cincinnati Rich Ellenbogen U. Washington Rob Friedlander Pittsburgh

5 Brigham alum in academia
Ian Johnson (MUSC) Adel Malek (Tufts) Don Matson (Brigham/BCH) Ernest Matthews (NYU/Hopkins/Mt. Sinai/MGH) Gordon McComb (USC) Robert McLaurin (Cincinnati) James McLennan (Cincinnati/Brown) Parker Mickle (Florida) Tom Moriarty (Louisville) Larry Page (Miami) John Park (NIH) John Shillito (Brigham/BCH) Phil Starr (UCSF) John Walsh (Kentucky/UT/Tulane) Simcha Weller (Tufts) John Adler (Stanford) Loren Amacher (Connecticut) Edgar Bering (NIH/Georgetown) Roc Chen (UT Houston) Robin Davidson (U. Mass) Kadir Erkmen (Dartmouth) Kai Frerichs (Brigham) August Giese (U. Missouri) Alex Golby (Brigham) Bruce Hendrick (Toronto) Michael Jerva (u. Illinois) Dennis Johnson (GWU/Penn St)

6 Brigham alumni in academia (since 2008)

7 Location of currently practicing NS Brigham Alumni

8

9 Quality metrics

10 The past: Neurosurgery Dept Location at Peter Bent Brigham Hospital -1913
The future: Neurosurgery Dept Location at: Institute for the Neurosciences (2016) Renovated PBB (2014)

11 Research funding

12 Teams

13 Neuro-oncology Programs in Neurosurgery
Harvey Cushing Neuro-oncology Laboratories (HIM 9) Mariano Viapiano, PhD: Glioma microenvironment and invasion Jakub Godlewski, PhD: microRNA biology in GBM Agnieszka Bronisz, PhD: The tumor “secretome” Sean Lawler, PhD: Glioma invasion Nino Chiocca, MD PhD: Biologic therapeutics Surgical Molecular Imaging Laboratory Nathalie Agar, PhD: In vivo tumor metabolomics linked with imaging Alex Golby, MD: Surgical imaging and brain mapping Laboratory of Cellular and Molecular Neuro-oncology Mark Johnson, MD PhD: Brain tumor genomics, stemness, invasion Skull base tumor laboratory Ian Dunn, MD PhD/ Ossama Al-Mefty, MD: Meningioma, pituitary adenoma, acoustic neuroma genomics Brain tumor epidemiology Liz Claus, MD PhD: Meningioma, GBM epidemiology and genetics The pituitary/neuroendocrine program Ed Laws, MD

14 Pituitary/Neuroendocrine Program
Edward R. Laws, Jr., MD, FACS and Colleagues Now >500 new patients per year 530 operations with minimally invasive 3D endoscopic surgery 20+ transsphenoidal operations in the AMIGO 3T intraoperative MRI suite Closing in on 6000 pituitary surgeries

15 Cases twice as likely as controls to report history of bitewing dental x-rays: OR=2.0 (1.4, 2.9)
Panorex at young age associated with increased risk: OR=4.9 (1.8, 13.2) Counter to ADA guidelines, the majority of subjects reported receiving dental x-rays on a yearly or greater frequency

16 Tumor Cell Concentration
Anaplastic Oligodendroglioma Tumor Cell Concentration 2HG Distribution Histopathology score 2HG intensity US Provisional Application No.: 61/747,330. Filed December 30, System and Method for Analysis of Bio-Metabolites Use in Image-Guided Surgery. Santagata,S., Eberlin, L.S., Norton, N., Ide, J.L., Liu, X., Wiley, J.S., Orringer, D., Gill, K.K., Dunn, I.F., Dias-Santagata, D., Ligon, K.L., Jolesz, F.A., Golby, A.J., Cooks, R.G., and Agar, N.Y.R. (Submission) Metabolite-imaging mass spectrometry to guide brain surgery. 16

17 Cerebrovascular Surgery
Kai Frerichs, MD PhD Endovascular Neurosurgery Rose Du, MD PhD Cerebrovascular Neurosurgery Ali Aziz-Sultan, MD Endovascular and Open Vascular Joining in October 2013 From Univ. of Miami Siekert Award (AHA): Platelet-activating Factor in brain injury NIH K08: Genomics of human aneurysms

18 Neuro-apoptosis drug discovery lab
Xin Wang, PhD

19 Melatonin offers neuroprotection in chronic Huntington’s disease (HD),
Amyotrophic lateral sclerosis (ALS), and acute ischemic stroke Melatonin slows disease progression in R6/2 HD mice. Melatonin delays disease onset 23% and extends survival 21% J Neurosci , J Neurosci , C. Melatonin reduces infract size in stroke Stroke, , B. Melatonin prolongs survival and restores Melatonin receptor 1A (MT1) in mSOD1G93A ALS mice Neurobiol Dis. , 26-35 Melatonin also prevents mitochondrial death pathways CNS Neurosci Ther , PNAS, , 19

20 Spine Surgery Michael Groff, MD Starting in July 2013 John Chi, MD MPH
Chairman Joint Section of Spine and Peripheral nerve Starting in July 2013 Yi Lu, MD PhD John Chi, MD MPH Harvard Catalyst Award

21 Functional Neurosurgery
Travis Tierney, MD PhD

22 Neurocritical Care William B Gormley, MD, MPH
Director of Neurosurgical Critical Care Brigham & Women’s Hospital Harvard Medical School Board Certification: American Board of Neurological Surgeons: Neurosurgery American Board of Surgery: Surgical Critical Care Neurosurgical Training Pathway to Critical Care Certification Work together with AANS to develop two tier certification for Neurosurgery trainees Level I Ability to take care of personal patients in an ICU setting Level II Fully certified Critical Care practictioner

23 Mitochondrial Injury and function
Bruce Kristal, PhD

24 Controlled Cortical Impact
Kristal Laboratory and Collaborators Imaging Biomarkers of TBI Rat mTBI Models Weight-Drop Fluid Percussion Controlled Cortical Impact Mitochondrial Targeted Neuroprotection X Fluid Biomarkers of TBI Integrated Biomarkers of mTBI Metabolomics and Lipidomics

25 Thank you! Centennial of the founding of the Department
Of Neurosurgery at the Brigham and Women’s Hospital ( )


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