1. Medical College of Wisconsin Functional Imaging Research Center Stephen M. Rao, Ph.D., Director Professor of Neurology http://www.firc.mcw.edu/

2. Scientific Advisory Board Jeffrey R. Binder, M.D. Alan S. Bloom, Ph.D. Edgar A. DeYoe, Ph.D Andrew S. Greene, Ph.D. Lotfi Hacein-Bey, M.D. Anthony G. Hudetz, Ph.D. James S. Hyde, Ph.D. Shi-Jiang Li, Ph.D. Thomas E. Prieto, Ph.D. Robert C. Risinger, M.D. Kathleen M. Schmainda, Ph.D. Reza Shaker, M.D. John L. Ulmer, M.D.

3. Members 33 Faculty from 10 MCW departments Anesthesiology, Biophysics, Cell Biology, Medicine, Neurology, Neurosurgery, Pharmacology, Physiology, Psychiatry, Radiology 5 faculty from Marquette and UW-Milwaukee 5 postdoctoral fellows 23 graduate students

4. Functional MRI at MCW Co-discovery of BOLD contrast effect in 1992: – Medical College of Wisconsin – Massachusetts General Hospital/Harvard – University of Minnesota Noninvasive technique for mapping human brain systems in healthy individuals: – vision, audition, motor control, emotions, language, attention, memory, reasoning, etc. More recent studies have applied this knowledge to various neurological patient populations

5. Imaging Infrastructure Three dedicated MR research scanners: – 3T GE short-bore Signa Excite scanner (located in teaching hospital) – 3T GE long-bore Signa Excite scanner (located in imaging building adjacent to research labs) – 9.4T Bruker scanner for animal research (also located in imaging building) PET-CT scanner at teaching hospital

6. MCW fMRI Funding Total extramural funding > $42 million (all years of active grants, direct + indirect costs) First fMRI PPG funded by NIH Largest number of fMRI patents Developed Analysis of Functional NeuroImages (AFNI) software

7. fMRI Training Training in Functional Neuroimaging Program (http://www.biophysics.mcw.edu/BRI-GradProg/MRGRAD.html) – funded since 1996 by NIMH – multidisciplinary graduate training program – Also supports postdoctoral training MCW fMRI Introductory Course (http://www.firc.mcw.edu/course) – Supported by GCRC Imaging Core – 3-day course, offered twice per year since 1997 – trained over 500 investigators from 13 countries GCRC physician scientist training/mentorship program

8. Clinical Science Applications Currently Funded Studies: – Dementias (Alzheimer’s disease) – Movement Disorders (Parkinson’s and Huntington’s diseases) – Cerebrovascular Disease (stroke) – Epilepsy – Neurodevelopmental disorders (ADHD) – Demyelinating Diseases (Multiple Sclerosis) – Drug Addiction (Cocaine, Nicotine, Marijuana) – Gastroenterological Disorders

9. fMRI Patient Applications Provide presurgical mapping tools Monitor disease progression Assess efficacy of new and existing treatments in clinical trials Provide earliest information on disease onset to initiate preventive treatments Better understand the neural mechanisms that support new and existing treatments Goal: to develop fMRI procedures/techniques that will have widespread clinical applicability

10. GCRC fMRI Core Core begun in 1996 to support clinical fMRI studies Annual budget: $647,000 DC Provides 6.6 FTEs, including: – MR Physicist – MR Technologists – System Analyst – Engineering Technician – Image Analysts – Educational Coordinator Payment of scanning fees for fMRI projects

11. GCRC-Supported fMRI Projects

12. GCRC fMRI Core Robert J. Thielke, Ph.D. GCRC Systems Manager Informatics Support

13. GCRC fMRI Core Tape backup server for fMRI analysis workstations (3TB tape library) Support for Linux and Mac workstations for data analysis Programming support in Labview, ePrime and Presentation software for data acquisition and task presentation Bioinformatics group developing web based database for fMRI studies – Subject information – Scanner settings – Tasks – Experiment classification Informatics Support