1. The single nephron GFR (SNGFR) can be affected by alterations in each of the four major determinants of ultrafiltration.
The single nephron GFR (SNGFR) can be affected by alterations in each of the four major determinants of ultrafiltration. These affects can be expressed in a mathematical model, which helps illustrate the predicted effects of each change on the SNGFR. Normal values are indicated with a dotted line in each graph. Unless otherwise indicated in the graph, the input values are Kf = nl/s·mmHg, = 35 mmHg, = 18 mmHg, and QA = 135 nl/min. (A) Alterations in Kf; (B) alterations in ; (C) alterations in ; (D) alterations in QA. Modified from Brenner BM, Dworkin LD, Ichikawa I: Glomerular filtration. In: Brenner and Rector’s The Kidney, 3rd Ed., edited by Brenner BM, Rector FC Jr, Philadelphia, Elsevier, 1986, with permission.
Martin R. Pollak et al. CJASN 2014;9:
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