1. Updates in Anticoagulation: What Did We Learn From ESC 2017?

2. COMPASS: Trial Design

3. COMPASS: Pantoprazole-Based Randomization

4. COMPASS: Outcomes

5. COMPASS: Primary Endpoints CV Death, Stroke, MI

6. COMPASS: Primary Components

7. COMPASS: Major Bleeding

8. COMPASS: Net Clinical Benefit

9. COMPASS: Summary

10. RE-DUAL PCI: Study Design Multicenter, Randomized, Open-Label PROBE Trial

11. RE-DUAL PCI: Primary Endpoint ISTH Major or CRNM Bleeding Event

12. RE-DUAL PCI: Rates of TIMI Major or Minor Bleeding

13. RE-DUAL PCI: Summary

14. IMPACT-AF: Cluster Randomized Trial

15. IMPACT-AF: Results Persistence and New Treatment

16. IMPACT AF: Clinical Outcomes

17. EMANATE: Study Design

18. EMANATE: Stroke/SE Outcomes

19. XANTUS: A Worldwide Program

20. XANTUS: Efficacy and Safety in the Real World

21. REHEARSE-AF

22. Abbreviations

23. Abbreviations (cont)