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Hironori Yoshida, MD, Young Hak Kim, MD  Journal of Thoracic Oncology 

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1 Successful Osimertinib Rechallenge after Severe Osimertinib-Induced Hepatotoxicity 
Hironori Yoshida, MD, Young Hak Kim, MD  Journal of Thoracic Oncology  Volume 12, Issue 5, Pages e61-e63 (May 2017) DOI: /j.jtho Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 (A and B) Computed tomography images before treatment with osimertinib. (C and D) Computed tomography images at the time of grade 4 hepatotoxicity showed a significant reduction of tumor size in the lungs, liver, and pleural effusion. Journal of Thoracic Oncology  , e61-e63DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Brain magnetic resonance imaging and chest computed tomography images before and after osimertinib rechallenge. (A and B) Images before osimertinib rechallenge. (C and D) At 5 months after osimertinib rechallenge, brain metastases, pulmonary tumor, and pleural effusion had decreased in size. Journal of Thoracic Oncology  , e61-e63DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

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