1. Hyperpolarized Helium 3 MRI in Mild-to-Moderate Asthma: Prediction of Postbronchodilator Reversibility
a b
Helium 3 (3He) MRI ventilation defects at year 1 predicted bronchodilator reversibility 6 years later (R2 = 0.80; P < .01).
In eight of 11 study participants, MRI ventilation defects remained in the same location at the 6-year follow-up MRI.
In three of 11 participants, MRI ventilation defects showed clinically significant worsening at the 6-year follow-up MRI in the same lung regions that had worsened in response to methacholine at year 1.
³He MRI ventilation in a 28-year-old with mild-to-moderate asthma and stable ventilation at (a) baseline and (b) follow-up shows persistent ventilation defects.
Eddy RL et al. Published Online: August 6, 2019