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Platelet-activating factor receptor antagonism improves cerebral recovery after circulatory arrest  Stephen M Langley, Paul J Chai, MD, James J Jaggers,

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Presentation on theme: "Platelet-activating factor receptor antagonism improves cerebral recovery after circulatory arrest  Stephen M Langley, Paul J Chai, MD, James J Jaggers,"— Presentation transcript:

1 Platelet-activating factor receptor antagonism improves cerebral recovery after circulatory arrest 
Stephen M Langley, Paul J Chai, MD, James J Jaggers, MD, Ross M Ungerleider, MD  The Annals of Thoracic Surgery  Volume 68, Issue 5, Pages (November 1999) DOI: /S (99)

2 Fig 1 Global and regional cerebral blood flow (CBF) at 1 hour of reperfusion after 60 minutes of deep hypothermic circulatory arrest (DHCA) at 18°C in control and ginkgolide B groups. Data are expressed as percentage of baseline CBF before DHCA (mean ± standard error of the mean) (HEMI = cerebral hemispheres; CBLM = cerebellum; BG = basal ganglia; BS = brain stem; ∗significantly greater percentage recovery than control group, unpaired t test p < 0.05; †no significant difference from pre-DHCA value within group, paired t test p > 0.05.) The Annals of Thoracic Surgery  , DOI: ( /S (99) )

3 Fig 2 Global and regional cerebral metabolic rate of oxygen (CMRO2) at 1 hour of reperfusion after 60 minutes of deep hypothermic circulatory arrest (DHCA) at 18°C in control and ginkgolide B groups. Data are expressed as percentage of baseline CMRO2 before DHCA (mean ± standard error of the mean) (HEMI = cerebral hemispheres; CBLM = cerebellum; BG = basal ganglia; BS = brain stem; ∗significantly greater percentage recovery than control group, unpaired t test p < 0.05; †no significant difference from pre-DHCA value within group, paired t test p > 0.05.) The Annals of Thoracic Surgery  , DOI: ( /S (99) )

4 Fig 3 Renal blood flow in control and ginkgolide B groups at initial baseline (Pre-DHCA) and at 1 hour of reperfusion (Post-DHCA) after 60 minutes of deep hypothermic circulatory arrest (DHCA) at 18°C. Data are expressed as mean ± standard error of the mean. (CDO2 = cerebral oxygen delivery; CEO2 = cerebral oxygen extraction; CMRO2 = cerebral metabolic rate of oxygen; ∗significant difference from pre-DHCA value within group, paired t test p < 0.05; †significant difference from control value post-DHCA, unpaired t test p < 0.05.) The Annals of Thoracic Surgery  , DOI: ( /S (99) )

5 Fig 4 Cerebral oxygen handling in the gingkolide B group (n = 7) at initial baseline (Pre-DHCA) and at 1 hour of reperfusion (Post-DHCA) after 60 minutes of deep hypothermic circulatory arrest (DHCA) at 18°C. Data are expressed as mean ± standard error of the mean. (CDO2 = cerebral oxygen delivery; CEO2 = cerebral oxygen extraction; CMRO2 = cerebral metabolic rate of oxygen; ∗significant difference from pre-DHCA value within group, paired t test p < 0.05; †significant difference from control value post-DHCA, unpaired t test p < 0.05.) The Annals of Thoracic Surgery  , DOI: ( /S (99) )

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